年龄、LH/FSH、AMH对体外受精-胚胎移植临床结局的预测价值

doi:10.3969/j.issn.1671-7171.2022.01.017

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Abstract 【Objective】To analyze the value of age, luteinizing hormone/basal follicle stimulating hormone (LH/FSH), and anti-Müllerian hormone (AMH) in predicting the clinical outcome of in vitro fertilization-embryo transfer (IVF-ET). 【Methods】A total of 186 patients (214 cycles) who underwent IVF-ET and had pregnancy outcomes in our hospital from February 2018 to December 2020 were selected as the research objects. Statistics of pregnancy outcome were divided into the pregnancy success group and pregnancy failure group according to whether the pregnancy was successful or not. the clinical data were compared between the successful pregnancy group and the pregnancy failure group. Logistic regression analysis was explored the relevant factors that affected the clinical outcome of IVF-ET assisted pregnancy. A receiver operating characteristic curve (ROC) was made, and the area under the curve (AUC) was used to analyze the predictive value of age, LH/FSH, AMH and the combination of the three on the clinical outcome of IVF-ET assisted pregnancy. 【Results】In this study, there were 76 successful pregnancy cases, the cycle clinical pregnancy rate was 40.86% and the clinical pregnancy rate was 35.51% (76/186). The pregnancy failure group's age, human gene recombinant follicle stimulating hormone (Gn) dosage, and FSH were all higher than the pregnancy success group (P<0.05), and the pregnancy failure group had lower embryo number, antral follicle number (AFC), LH/FSH, and AMH compared to the successful pregnancy group (P<0.05). Logistic multivariate analysis showed that age, number of embryos transferred, LH/FSH and AMH were the related factors affecting the clinical pregnancy outcome of IVF-ET assisted women (OR=3.522, 2.852, 3.770, 4.108, P<0.05). ROC analysis showed that the best cut-off points of age, LH/FSH, and AMH for predicting the clinical outcome of IVF-ET assisted fertility were 31.96 years, 1.79 μg/L and 3.28 μg/L, respectively. The specificity of the combination of the three was 98.39%, which was higher than the specificity evaluated by age, LH/FSH and AMH alone. The AUC predicted by the combination of age, LH/FSH, and AMH for clinical outcome of IVF-ET assisted fertility was 0.896, which was significantly higher than the AUC predicted by age, LH/FSH and AMH alone (P<0.05). 【Conclusion】The combination of age, LH/FSH and AMH has a high value in predicting the clinical outcome of IVF-ET, and it is suitable as an important reference index for clinical prediction of the clinical outcome of IVF-ET assisted pregnancy.

Key words： Fertilization in Vitro/MT Embryo Transfer/MT Age Factors Gonadal Steroid Hormones Pregnancy Outcome

Received: 02 September 2021

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R321-33

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	CAO Yang-yang
	CHANG Wang-yan

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CAO Yang-yang,CHANG Wang-yan. Analysis of the Value of Age, LH/FSH, and AMH in Predicting the Clinical Outcome of in Vitro Fertilization-Embryo Transfer[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(1): 63-66.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.01.017 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I1/63

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