Expression and Clinical Significance of M-CSF and β-Catenin in the Serum of Patients with Severe Preeclampsia
LIU Yan-yun, YAN Xiao-yan, LI Yun
Department of obstetrics,Huangshi Maternity & Children's Health Hospital,Edong Healthcare Group/Women's & Children's Hospital Afflicated to Hubei Polytechnic University,Huangshi Hubei 435003,China
Abstract 【Objective】To explore the relationship between the expression of macrophage colony stimulating factor (M-CSF) and β-catenin (β-Catenin) in the serum of patients with severe pre-eclampsia (PE) and its clinical significance. 【Methods】There were 51 patients with early-onset severe PE and 51 cases of late-onset severe PE were selected in each group. The serum M-CSF and β-Catenin cytokine expression levels, clinical biochemical indicators and pregnancy complications were compared between the two groups, and their interaction relationship was analyzed. 【Results】 The expression levels of serum M-CSF and β-Catenin factor in the early-onset severe PE group were higher than those in the late-onset severe PE group, the difference was statistically significant (P<0.05). Pearson correlation analysis showed that the relationship of M-CSF and β-Catenin expression in the serum of patients with severe PE was significantly positively correlated (r=0.75, P=0.00＜0.01). The quantitative levels of serum creatinine (SCr), blood urea nitrogen (BUN), blood uric acid (UA) and 24h urine protein (24hpro) in patients with early-onset severe PE were significantly higher than those in patients with late-onset severe PE, and the differences were statistically significant ( P<0.05). The incidence of complications in the early-onset severe PE group was 78.43% (40/51), which was significantly higher than 35.29% (18/51) in the late-onset severe PE group, and the difference was statistically significant (χ2=10.77,P=0.02).【Conclusion】 The expression of serum M-CSF and β-Catenin in patients with severe preeclampsia plays a synergistic role in the pathogenesis of PE, and is closely related to the severity of the disease and the incidence of complications. Clinical diagnosis of severe PE needs to be confirmed as soon as possible, so active treatment measures can be put properly to improve pregnancy outcome.
LIU Yan-yun,YAN Xiao-yan,LI Yun. Expression and Clinical Significance of M-CSF and β-Catenin in the Serum of Patients with Severe Preeclampsia[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(11): 1618-1620.
2021, Vol. 38 
