原发性醛固酮增多症患者糖代谢特点及其相关影响因素研究

doi:10.3969/j.issn.1671-7171.2021.10.017

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Abstract 【Objective】To explore the related factors of abnormal glucose metabolism in patients with primary aldosteronism (PA). 【Methods】The clinical data of 195 patients with PA first diagnosed in the Department of Cardiology of our hospital from January 2015 to December 2019 (observation group) were analyzed retrospectively, and 195 patients with essential hypertension were included as the control group. The blood glucose metabolism indexes, blood lipid level, consulting room blood pressure and ambulatory blood pressure of the two groups were compared. The effects of renin, aldosterone and aldosterone/renin activity ratio (ARR) on blood glucose metabolism indexes were analyzed by multiple linear regression. 【Objective】The course of hypertension, body mass index (BMI), the proportion of abnormal glucose metabolism, fasting blood glucose (FPG), glycosylated hemoglobin (HbAc1), K, aldosterone and ARR in the observation group were higher than those in the control group, and the renin level and the proportion of women in the observation group were lower than those in the control group (P<0.05). The consulting room blood pressure, 24-hour blood pressure, daytime and nighttime blood pressure in the observation group were higher than those in the control group, and the decrease rate of nighttime systolic blood pressure was lower than that in the control group (P<0.05). The proportion of FPG and abnormal glucose metabolism and diabetes in patients with PA adrenal hyperplasia were higher than those in adrenal adenomas (P<0.05). Multiple linear regression analysis showed that FPG and HbAc1 levels were independently correlated with aldosterone levels (P<0.05). 【Conclusion】The blood glucose level in PA patients is higher than that in pH patients. The aldosterone level is independently related to the increase of FPG and HbAc1.

Key words： Hyperaldosteronism Blood Glucose/ME Root Cause Analysis

Received: 25 September 2020

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R586.24

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.10.017 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I10/1500

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