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| Exploration of Phase Angel Combined with Fat Free Mass Index or Relative Appendicular Skeletal Muscle Index to Define Malnutrition of peri- Hematopoietic Stem Cell Transplantation Patients |
| FENG Guo, LIU Hong, WANG Meng,et al |
| The Third Xiangya Hospital, Central South University, Changsha, 410013 |
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Abstract 【Objective】 This research is aimed to explore the significance of phase angle(PA) combined with fat-free body mass index(FFMI) or relative limb skeletal muscle index(RAMS) in the evaluation of malnutrition in peri-hematopoietic stem cell transplantation(HSCT) patients. 【Methods】A total of 98 patients treated with HSCT were recruited for the study. The nutritional risk was assessed by Nutritional Risk Screening 2002(NRS2002) and malnutrition status was diagnosed according to standard of GLIM. PA, FFMI and RAMS were tested by Bio Impedance Analysis(BIA). Correlations among PA, FFMI and RAMS were analyzed by Pearson analysis. The combined data of PA and FFMI and combined data of PA and RAMS of 98 patients were calculated by Logistic analysis. The ROC analysis was used to detect the area under the curve(AUC) of PA, FFMI, RAMS, PA combined with FFMI, and PA combined with RAMS. 【Results】The positive rate of NRS2002 in peri-hematopoietic stem cell transplantation patients was 100%. It showed the strong positive relationship of PA with FFMI and PA with RAMS(P<0.01). Using GLIM criteria as the standard for the diagnosis of malnutrition, the area under the ROC curve of PA, FFMI, and RAMS were 0.308, 0.204 and 0.270, respectively(P<0.01). The area under the ROC curve of the combined data of PA and FFMI and the combined data of PA and RAMS were 0.791 and 0.737(P<0.01). 【Conclusion】PA, FFMI and RAMS alone have poor accuracy in diagnosing malnutrition, but the combined data of PA and FFMI and the combined data of PA and RAMS are more accurate in diagnosing malnutrition. It is suggested that combining PA with FFMI and PA with RAMS may provide evidence for malnourished diagnosis.
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Received: 25 February 2021
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2021, Vol. 38 
