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| Study on the Association Between HLA-G Gene Polymorphism and Patients with Rheumatoid Arthritis |
| WU Fei, LIU Ting, YAN Xiang-hong |
| Changsha Central Hospital,Changsha Hunan 410004 |
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Abstract 【Objective】 To investigate the association between HLA-G allele polymorphism and the incidence of rheumatoid arthritis (RA) and the production of rheumatoid factor (RF). 【Methods】 through confirmed 95 cases of RA patients and 110 health examiner, to extract all the object of study after peripheral blood, with the method of polymerase chain reaction sequence specific primers (PCR-SSP method) on the research object of HLA-G allele specific amplification and sequencing of the HLA-G type don't statistical analysis, compare the HLA -G allele in the distribution of the frequency of the differences between different groups, and chi-square test for statistical analysis. 【Results】 There was no significant difference in the distribution frequency of four HLA-G alleles between RA group and control group (P>0.05).There was no significant difference in the distribution frequency of four HLA-G alleles between RF positive and RF negative patients in RA group (P>0.05). 【Conclusion】 No difference in the distribution frequency of HLA-G allele was found between RA patients and the normal population, and no protective or susceptible HLA-G allele associated with RA was found. HLA-G may not be directly related to the incidence of RA and the generation of RF.
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Received: 19 March 2021
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2021, Vol. 38 
