Correlation Analysis of Serum Apolipoprotein A1, B levels with the Number of Coronary Artery Lesions and Gensini Score in Patients with Coronary Heart Disease
ZOU Jin-guo, CHEN Xiao-qiang, XU Rui
The Third Hospital of Xi'an City, Shaanxi Province, 710000
Abstract【Objective】To analyze the correlation between serum apolipoprotein A1 (ApoA 1) and B (ApoB) and the number of coronary artery lesions and Gensini score in coronary heart disease (CHD). 【Methods】A total of 300 cases of CHD patients treated in Xi'an Third Hospital and People's Hospital of Xinjiang Autonomous Region from March 2016 to October 2018 were selected and divided into acute myocardial infarction (AMI) group (n=86), unstable angina pectoris (UAP) group (n=102), stable angina group (SAP) group (n=112). Coronary artery lesions were examined by angiography and Gensini score was performed. The serum ApoA 1 and ApoB were detected. The correlation between serum levels of apolipoprotein A1 and B and the number of coronary artery lesions and Gensini score was analyzed. 【Results】 The serum AopA1 level of the SAP group was the highest, the UAP group was the second, the AMI group was the lowest; the serum ApoB level of the AMI group was the highest, the UAP group was the second, the SAP group was the lowest, the differences were statistically significant (P<0.05). The proportion of multi vessel lesions and Gensini score of the AMI group were the highest,the UAP group was the second, the SAP group was the lowest, the difference was statistically significant (P<0.05). Pearson analysis showed that AopA1 was negatively correlated with the number of coronary artery lesions and Gensini score (r=-0.690, -0.653, P<0.001), while ApoB was positively correlated with it (r=0.713, 0.685, P<0.001). 【Conclusion】Serum ApoA1 and apoB levels are correlated with the number of coronary artery lesions and Gensini score in CHD patients.
ZOU Jin-guo,CHEN Xiao-qiang,XU Rui. Correlation Analysis of Serum Apolipoprotein A1, B levels with the Number of Coronary Artery Lesions and Gensini Score in Patients with Coronary Heart Disease[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(12): 1853-1855.
[1] 刘许增,余新东,罗才福,等.经皮冠状动脉介入治疗冠心病的临床效果及对患者血清VEGF水平的影响[J].医学临床研究,2020,37(7):961-963. [2] 杨斌,赵宝珍,江时森,等.冠状动脉粥样硬化与脂质过氧化损伤和血管内皮功能之间的关系[J].医学研究生学报,2004,17(2):136-138. [3] 刘瑶,李俊峰,王安伟,等.瑞舒伐他汀联合复方丹参治疗冠心病合并高胆固醇血症患者的效果及其对载脂蛋白A1,载脂蛋白B和脂蛋白酯酶水平的影响[J].中国医药导报,2016,13(7):123-126. [4] 刘红娜,张悟棠.炎症因子与冠状动脉粥样硬化的关系及其在介入治疗后变化[J].中西医结合心脑血管病杂志,2016,14(8):848-852. [5] 由凤秋,董亚茹,狄政莉,等.动脉硬化性脑梗死患者血清高密度脂蛋白胆固醇、载脂蛋白A1、低密度脂蛋白胆固醇、载脂蛋白B水平及其比值的变化[J].卒中与神经疾病,2013,20(5):287-289. [6] 冯燕娴,石增刚,汤凤英,等.血清载脂蛋白B、载脂蛋白B载/脂蛋白A1值与冠状动脉病变的相关性分析[J].东南大学学报(医学版),2011,30(4):577-580. [7] Jungner I, Sniderman AD, Furberg C, et al. Does low-density lipoprotein size add to atherogenic particle number in predicting the risk of fatal myocardial infarction[J].Am J Cardiol,2006, 97(7): 943-946. [8] 王晓晨,徐岩,程自平,等.血清载脂蛋白A-1、载脂蛋白B和脂蛋白(a)与冠心病相关性的临床分析[J].安徽医科大学学报,2009,44(3):395-398. [9] 刘姗姗,王璐,邱建平.血清载脂蛋白A1、载脂蛋白B及其比值与冠脉病变程度相关性分析[J].中国实验诊断学,2013,17(7):1216-1218. [10] Johnson JS, Fisher RM, Corral AB, et al. Concentration of apotipoprotein B is comparable with the apolipoprotein B/Apolipoprotein A-1 ratio and better than routine clinical Lipid measurements in predicting coronary heart disease mortality: Finding from a multi-ethnic US population [J].Eur Heart J,2009, 30(6): 710-717.
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(9): 1436-1438.
2020, Vol. 37 
