雷珠单抗联合微脉冲激光治疗视网膜分支静脉阻塞继发黄斑水肿的疗效观察

doi:10.3969/j.issn.1671-7171.2020.08.011

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Abstract 【Objective】 To investigate the clinical efficacy of intravitreal injection ranibizumab combined with 532nm subthreshold micropulse laser photocoagulation treatment for macular edema (ME) secondary to branch retinal vein occlusion (BRVO). 【Methods】 A total of 30 patients (30 eyes) with macular edema secondary to branch retinal vein occlusion were randomly divided into the control group (with ranibizumab therapy) and the observation group (ranibizumab combined with 532nm subthreshold micropulse laser therapy).The best corrected visual acuity(BCVA),central macular thickness(CMT), repeated injection times and complications were compared between the two groups before and after treatment. 【Results】 After treatment, patients' BCVA of the two groups decreased; And the difference was statistically significant compared to that before treatment (P<0.05). However, there was no statistically significant difference in BCVA between the two groups at each time point (P>0.05). The CMT of the two groups gradually decreased after treatment, and the difference was statistically significant compared with that before treatment (P<0.05). There was no significant difference within the observation group only at d7 and 1 month after treatment (t=0.954,P>0.05); The differences at the remaining time points within the observation group showed statistically significant (P<0.05). Patients in the observation group had an average intraocular injection (1.73±0.96) times, which was significantly lower than the control group (3.07±0.70) times. The difference was statistically significant (P<0.05). No serious eye and systemic adverse reactions occurred during follow-up. 【Conclusion】 Intravitreal injection ranibizumab combined with 532nm subthreshold micropulse laser photocoagulation shows effective treatment for macular edema secondary to branch retinal vein occlusion, which can improve condition of macular edema and vision. It also reduces the number of intraocular injection.

Key words： Retinal Vein Occlusion/TH Macular Edema/TH Laser Therapy

Received: 28 November 2019

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R774.5

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.08.011 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I8/1154

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