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| Effects of Multimode Analgesic Protocol on Analgesia, Hemodynamic and Inflammatory Factors in Patients with Gynecological Laparoscopy |
| LUO Hai-ming, JIN Shan-liang, QUAN Zong-zong |
| Shanghai Jiaotong University School of Medicine 201900 |
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Abstract 【Objective】 To investigate the effect of multi-mode analgesia on analgesia, hemodynamics and inflammatory factors in patients undergoing gynecological laparoscopic surgery.【Methods】 A total of 136 patients who underwent gynecological laparoscopic surgery in our hospital were selected and divided into two groups by random. The control group was given the traditional single analgesic regimen, while the observation group was given the multi-mode analgesic regimen. The analgesic effect, hemodynamics and inflammatory factors between the two groups were compared. 【Results】 The dosage of fentanyl in the observation group was lower than that in the control group (P>0.05).However, no significant differences were shown in the dosage of opioid drugs and the days of hospitalization after operation between the two groups (P>0.05). The heart rate (HR) and level of mean arterial pressure (MAP) between the two groups before induction (T0)and at 5min (T1) after anesthesia induction did not show significant difference (P>0.05).The levels of MAP and HR in the observation group were lower than those in the control group (P<0 05) immediately after operation (T2), at the end of operation (T3) and immediately after extubation (T4). There were no statistically significant differences in the levels of TNF-α and IL-6 between the two groups before surgery(P>0.05). While the levels of TNF-α and IL-6 in the observation group were lower than those in the control group at 30 minutes, 2 hours and 24 hours after operation (P<0 05). There was no significant difference in VAS scores between the two groups at 10 min after extubation (P>0 05). The scores of VAS in the observation group were lower than those in the control group at 6 h, 12 h and 24 h after operation (P<0.05). 【Conclusion】 The application of multi-mode analgesia in gynecological laparoscopic surgery can stabilize the level of MAP and HR, inhibit the expression of inflammatory factors, and alleviate the pain degree of patients.
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Received: 15 July 2019
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2020, Vol. 37 
