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| Expression and Clinical Significance of LIMK1 and Cofilin Expression in Prostate Cancer |
| SHI Tao, HANG Zhen-yu, SHEN Lu-ming |
| Urology of Liyang people's Hospital, Jiangsu Liyang 213300 |
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Abstract 【Objective】 To investigate the correlation of the expression of LIM-kinase1 (LIMK1) and Cofilin with clinicopathological features and prognosis of prostate cancer.【Methods】 In this study, protein expression levels of LIMK1 and Cofilin in tissues measured by immunohistochemistry were collected from 93 cases of prostate cancer and 51 cases of benign prostatic hyperplasia treated in our hospital from September 2015 to June 2018. The correlations of LIMK1 nad Cofilin with their clinicopathological features and prognosis were analyzed. 【Results】 The positive rates of LIMK1 and Cofilin protein in prostate cancer tissues were significantly higher than those in benign prostatic hyperplasia (P<0.05). The expression levels of LIMK1 and Cofilin protein in prostate cancer patients with different prostate volume, seminal invasion, lymph node metastasis, capsule invasion, positive margin, PSA level, PSAD, Gleason score and clinical T stage were significantly different (P<0.05). The expressions of LIMK1 and Cofilin were significantly associated with the survival rate of prostate cancer patients (P<0.05). The expression of LIMK1 protein was positively correlated with Cofilin expression in prostate cancer tissues (P<0.05). 【Conclusion】 Both LIMK1 and Cofilin are positively expressed in prostate cancer tissues, which are correlated to the prostate volume, seminal invasion, lymph node metastasis, capsule invasion, positive margin, PSA level, PSAD, Gleason score and clinical T stage; meanwhile, the lymph node metastasis, capsule invasion, positive margin, Gleason score, T stage and protein expression levels of LIMK1 and Cofilin are associated with the survival rate of prostate cancer patients. Thus, LIMK1 and Cofilin protein expression levels can be serves as indicators for diagnosis and prognosis of prostate cancer.
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Received: 20 November 2018
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2020, Vol. 37 
