|
|
|
| Anesthetic and Coagulation Effects of Fentanyl Combined with Dexmedetomidine on Percutaneous Vertebroplasty in Patients with Vertebral Compression Fracture |
| XUE Na, WU Li, WU Xian-wei, et al |
| Honghui Hospital of Xi'an Jiaotong Unviersity, Shaanxi, Xi'an 710054 |
|
|
|
|
Abstract 【Objective】To investigate the anesthetic and coagulation effects of fentanyl combined with dexmedetomidine(Dex)on percutaneous vertebroplasty( PVP) in patients with vertebral compression fractures. 【Methods】A total of 94 patients with vertebral compression fractures underwent PVP were divided into the control group (n=47) and the observation group. (n=47) with random number table method. The control group was given remifentanil combined with propofol anesthesia. While the observation group was anesthetized with fentanyl and Dex . The anesthetic effect, coagulation function and safety were compared between the two groups. 【Results】The anesthesia recovery time and extubation time of the observation group were all shorter than those of the control group (P<0.05). The VAS score of the observation group was lower than that of the control group (P<0.05). The Ramsay sedation score of the observation group was higher than that of the control group (P<0.05). The time of PT and APTT in the observation group was longer than those in the control group, while the fibrinogen (FIB) and platelet (PLT) levels in the observation group were lower than those in the control group (P<0.05). There was no significant difference in safety between the two groups after operation (P>0.05). 【Conclusion】Fentanyl combined with dexmedetomidine achieves good anesthetic effect on percutaneous vertebroplasty in patients with vertebral compression fractures. It can improve coagulation function with safe clinical application.
|
|
Received: 19 December 2018
|
|
|
|
|
|
[1] Lee JM, Lee SK, Lee SJ,et al. Comparison of remifentanil with dexmedetomidine for monitored anaesthesia care in elderly patients during vertebroplasty and kyphoplasty[J].J Int Med Res,2016, 44(2):307-316.
[2] 高峰,吴雨佳.右美托咪定对静吸复合麻醉骨折手术患者苏醒期躁动及术后机械痛阈值的影响[J].山东医药,2016,56(28):100-102.
[3] 唐润栋,徐晓林,姜彦,等.右美托咪定复合舒芬太尼术后镇痛对经腹子宫切除术患者睡眠质量的影响[J].临床麻醉学杂志,2017,33(3):222-225.
[4] 胡志成,凌建忠,黄玉,等.右美托咪定复合小剂量芬太尼在监测麻醉下经皮椎体成形术中的应用[J].实用临床医药杂志,2015,19(19):135-136.
[5] Peng K, Liu H Y, Liu S L, et al. Dexmedetomidine-fentanyl compared with midazolam-fentanyl for conscious sedation in patients undergoing lumbar disc surgery[J].Clin Therapeutics,2016, 38(1):192-201.e2.
[6] 万军芳,刘金东,程芳,等.右美托咪定联合芬太尼对下肢骨折术后静脉自控镇痛的影响[J].徐州医学院学报,2014,34(1):51-53.
[7] Choi J W, Joo J D, Kim D W, et al. Comparison of an intraoperative infusion of dexmedetomidine,fentanyl, and remifentanil on perioperative hemodynamics,sedation quality, and postoperative pain control[J].J Korean Med Sci,2016, 31(9):1485-1490.
[8] 汪树东,李娟,康芳,等.不同靶控浓度瑞芬太尼联合右美托咪定用于颈椎手术麻醉中经鼻清醒气管插管效果的比较[J].临床麻醉学杂志,2016,32(6):535-538. |
|
|
|
2019, Vol. 36 
