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| Expression of CAP2 Gene in HCC and its Prognostic Value |
| LUO Li-hua, WANG Lan-qing, LUO Liu-fang,et al |
| Department of Cancer Center, Affiliated union hospital of huazhong university of science and technology , Wuhan 430022, China |
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Abstract 【Objective】To investigate the expression of CAP2 gene in HCC and its prognostic value.【Methods】The HCC related gene CAP2 was screened in Oncome database, and then the secondary analysis was carried out in Oncome and CCLE database, and the prognosis analysis was carried out in gepia database. 【Results】Based on Oncome database, the analysis of HCC miRNA microarray showed that CAP2 was up-regulated most significantly in HCC gene expression profile. A total of 412 different CAP2 studies were included in oncoming database, among which 33 were statistically significant, 14 were highly expressed, and 19 were low expressed. A total of 8 studies found that CAP2 was highly expressed in HCC (P<0.05), a total of 646 samples; then CCLE data was used to verify the expression level of CAP2 in HCC cells, and the results showed that CAP2 was highly expressed, consistent with oncomine. There was correlation between CAP2 and the disease-free survival rate of HCC patients (P<0.05), but not with the overall survival rate (P>0.05); the disease-free survival rate of patients with high expression of CAP2 was poor, and the disease-free survival rate of patients with low expression of CAP2 was better. 【Conclusion】CAP2 is highly expressed in HCC tissues and cells, and is related to the prognosis of HCC. It provides biomarkers for the new diagnosis and prognosis of HCC.
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Received: 07 May 2019
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(9): 1773-1775. |
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2019, Vol. 36 
