|
|
|
| Effect of Propranolol on the Expression of VEGF and its Receptors VGFR1/VEGFR2 in Serum of Children with Hemangioma |
| LI Lei, LIANG Wei, CHEN Chen,et al |
| Hebei general hospital, Shijiazhuang, hebei,050000,China |
|
|
|
|
Abstract 【Objective】To investigate the effect of propranolol on the expression of VEGF and its receptorsVGFR1/VEGFR2 in serum of children with hemangioma. 【Methods】From December 2014 to December 2017, 48 children with hemangioma in our hospital were selected. All the children were given propranolol orally (0.5 mg/kg for less than 3 months, 1 mg/kg for 3~6 months, 2 mg/kg for more than 6 months, twice a day, a total of 3 months). The levels of VEGF and its receptors VGFR1/VEGFR2 , were recorded before and 3 months after treatment. The tumor volume of the observation group before and 3 months after treatment was measured by ultrasound and the curative effect was evaluated. 【Results】 After one course of treatment, the levels of VEGF and its receptor VGFR1/VEGFR2 protein and mRNA expression in serum were significantly lower than those before treatment (P<0.05). The volume of hemangioma after treatment was (0.29 ± 0.09) cm3, which was significantly lower than that before treatment (0.78 ± 0.15) cm3, the difference was statistically significant (P<0.05). After treatment, Achauer method was used to evaluate the therapeutic effect, including 20 excellent cases, 15 good cases, 7 fair cases and 6 poor cases. The excellent and good rate was 72.9%.【Conclusion】The clinical effect of propranolol is better in children with hemangioma. The mechanism may be related to the down-regulation of serum VEGF and its receptor VGFR1/VEGFR2 expression levels.
|
|
Received: 31 January 2019
|
|
|
|
|
|
[1] McCormick AA,Tarchichi T,Azbell C,et al.Subglottic hemangioma: Understanding the association with facial segmental hemangioma in a beard distribution[J].Int J Pediatr Otorhinolaryngol,2018,113(26):34-37.
[2] 方兴. 肿瘤抑素影响血管瘤内皮细胞凋亡的相关机制分析[J].临床和实验医学杂志, 2018,17(4):370-371.
[3] Léauté-Labrèze C.Propranolol for severe hemangiomas of infancy[J].New Engl J Med,2008,358(24):2649-2651.
[4] LéautéLabrèze, Christine, Hoeger P , Mazereeuwhautier J,et al. A randomized, controlled trial of oral propranolol in Infantile Hemangioma -NEJM[J].J Vascular Surg,2015, 62(2):518-519.
[5] Li L L , Yan L , Luo M X , et al. Propranolol in the treatment of infantile hemangiomas: a meta-analysis in Chinese patients[J].Pediatric Dermatol,2015, 32(5):e210-e214.
[6] Yamashita T,Jinnin M,Makino K,et al.Serum cytokine profiles are altered in patients with progressive infantile hemangioma[J].Biosci Trends,2018,12(4):438-441.
[7] Oszajca K,Szemraj J,Wyrzykowski D,et al.Single-nucleotide polymorphisms of VEGF-A and VEGFR-2 genes and risk of infantile hemangioma[J].Int J Dermatol,2018,57(10):1201-1207.
[8] Ugˇur Keskin, Ulubay M , Dede M , et al. The relationship between the VEGF/sVEGFR-1 ratio and threatened abortion[J].Arch Gynecol Obstetr,2015, 291(3):557-561.
[9] Kapahi R, Guleria K, Sambyal V,et al. Association of VEGF and VEGFR1 polymorphisms with breast cancer risk in North Indians[J].Tumor Biol,2015, 36(6):4223-4234.
[10] Kagami S,Kaneko M,Kishi A.Prolonged growth of infantile hemangioma after pulsed dye laser and oral propranolol treatment[J].J Dermatol,2018,45(9):1109-1112.
[11] Strumila A,Dagilyte. RV.Recommendations and a guideline for referral of infantile haemangioma to tertiary centres[J].Acta Med Litu,2018,25(1):38-44. |
|
|
|
2019, Vol. 36 
