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| Correlation of BRAF V600E Mutation and Microsatellite Instability with Prognosis in Colorectal Cancer Patients |
| HE Xing-zhuang, YANG Zheng-bing, MOU Hui |
| Department of Pathology, First People's Hospital of Guangyuan City, Guangyuan Sichuan 628000, China |
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Abstract 【Objective】To investigate the relationship of microsatellite instability (MSI) and BRAF V600E mutation with clinicopathological features and prognosis of patients with advanced stages of colorectal cancer (CRC). 【Methods】A total of 82 patients with radical resection of colorectal cancer admitted to our hospital from May 2014 to May 2015 were enrolled. The clinical data and surgical resection specimens of patients were collected. All patients were followed up for 3 years and the survival status of the patients was recorded. The relationship among MSI, BRAF V600E mutation and clinicopathological features were analyzed and compared. Furthermore the correlation of the value of BRAF V600E mutation in different microsatellite stable (MSS) subgroups with the prognosis of CRC patients was investigated as well. 【Results】Lymph node metastasis (N1) was more frequently observed in MSI-H patients, poorly differentiated tissues, BRAF V600E mutation and right-sided tumors were in a larger proportion in MSI-H patients. Compared to BRAF V600E wild type patients, the BRAF V600E mutant patients had a higher proportion of poorly differentiated cancer and lower disease-free survival rate. In the MSS group, the disease-free survival rate of patients with BRAF V600E mutation was significantly lower than that of BRAF V600E wild type patients. So BRAF V600E mutation was an independent risk factor for the prognosis of patients with CRC, especially MSS. 【Conclusion】Combining the detection of microsatellite instability and BRAF V600E mutation can effectively predict the prognosis of colorectal cancer patients.
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Received: 30 July 2018
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2019, Vol. 36 
