PR-A、PR-B、PR-M在子宫肌瘤组织中的表达及其临床意义

doi:10.3969/j.issn.1671-7171.2019.05.027

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To observe the expression levels of PR-A, PR-B and PR-M in uterine leiomyoma tissues and analyze their clinical significance. 【Methods】Patients with uterine leiomyoma who were treated in our hospital from March 2017 to May 2018 were selected as the observation objects. The expression levels of PR-A, PR-B and PR-M in uterine leiomyoma and normal tissues were observed. The expression levels of PR-A, PR-B and PR-M in patients with different characteristics of uterine leiomyoma were compared. The factors influencing the expression of PR-A, PR-B and PR-M in patients with uterine leiomyoma were analyzed. 【Results】The expressions of PR-A, PR-B and PR-M in uterine leiomyoma were 0.79±0.09, 0.93±0.10, 0.09±0.005, higher than those in normal tissues (P<0.001); the expressions of PR-A, PR-B and PR-M were higher in patients with uterine leiomyoma whose number of leiomyomas was more than 2 and the diameter of leiomyoma was more than 5 cm. The expressions of PR-A, PR-B and PR-M were higher in patients with uterine leiomyoma at different ages, reproductive history, hypertension and diabetes mellitus. The expression levels of PR-A, PR-B and PR-M protein in leiomyoma tissues of patients with uterine leiomyoma were not affected (P>0.05). Multivariate regression analysis showed that the diameter of leiomyoma and the number of leiomyomas were the influencing factors of the expression of PR-A, PR-B and PR-M protein in patients with uterine leiomyoma. 【Conclusion】The expression of PR-A, PR-B and PR-M in uterine leiomyoma is high, and is affected by the number of leiomyoma and the diameter of leiomyoma.

Key words： Uterine Neoplasms/PP Proteins

Received: 12 March 2019

PACS:

R737.3

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	PU Dan
	ZHANG Chuan-li

Cite this article:

PU Dan,ZHANG Chuan-li. Expression and Clinical Significance of PR-A, PR-B and PR-M Proteins in Uterine Leiomyoma[J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(5): 914-916.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2019.05.027 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2019/V36/I5/914

[1] Chantraine F, Poismans G, Nwachuku J,et al. Expulsion of a uterine myoma in a patient treated with ulipristal acetate[J].Clin Case Rep,2015,3(4):240-242.
[2] Shirota K, Itoh H, Anan H, et al. A case of secondary amenorrhea caused by uterine myoma successfully treated by a combined laparoscopic and hysteroscopic approach[J].Gynecol Minim Invasive Ther,2017,6(1):49-50.
[3] 封全灵,王智霆,刘慧云. 子宫肌瘤细胞中孕激素受体M、A/B及porin蛋白表达观察[J].山东医药,2017,57(15):45-47.
[4] 子宫肌瘤的诊治中国专家共识专家组. 子宫肌瘤的诊治中国专家共识[J].中华妇产科杂志,2017,52(12):793-800.
[5] 温丽娜,汪玉芳,谭俐,等. 广州市白云区子宫肌瘤的流行病学调查及其危险因素分析[J].中国妇幼保健,2018,33(3):634-636.
[6] Aksoy H, Aydin T, zdamar ,et al. Successful use of laparoscopic myomectomy to remove a giant uterine myoma: a case report[J].J Med Case Rep,2015,9(1):103-106.
[7] 廖治,肖洪涛. MicroRNA-18a及雌激素受体α在子宫肌瘤中的表达[J].中国临床药理学杂志,2015,25(21):2128-2130.
[8] 封全灵,熊祯祯,王智霆,等. 米非司酮对孕激素受体M阳性子宫肌瘤细胞增殖、凋亡的影响[J].山东医药,2017,57(3):13-15.
[9] 李亮,宋成文,杨赛花,等. IGF-Ⅰ、IGF-Ⅱ、ER及PR在子宫组织的表达及肌瘤复发的意义[J].中国妇幼保健,2015,30(17):2874-2876.
[10] 吴海莉,宋燕,周莹莹,等. 子宫肌瘤组织SULT1E1和ERα、ERβ、PRA、PRB受体蛋白的表达及临床意义[J].现代肿瘤医学,2015,23(10):1419-1424.
[11] 李楠,贺丰杰,李小宁,等. 宫瘤消胶囊对子宫肌瘤模型大鼠雌孕激素水平及其受体表达的影响[J].中国妇产科临床杂志,2015,16(6):534-537.
[12] 梁晓兰,杨永秀. 子宫肌瘤发病的相关危险因素Logistic回归分析[J].中国医学前沿杂志(电子版),2015,7(2):102-105.
[13] 刘冉,陶国伟,甄军晖,等. ER、PR在妊娠期子宫肌瘤组织中的表达及意义[J].山东大学学报:医学版,2016,56(5):45-49.