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| Analysis of Correlation between NT-proBNP and UA Levels and Cardiac Function Classification and Prognosis in Patients with Chronic Heart Failure |
| ZENG Lei, LIU Zhi-hong |
| Traditional Chinese Hospital of LuAn, 237000, Anhui,Province |
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Abstract 【Objective】To study the correlation of cardiac function classification and prognosis with the level of NT-proBNP and uric acid of elderly patients with chronic heart failure. 【Methods】The clinical data of 70 elderly patients with chronic heart failure admitted to our hospital from October 2016 to August 2017 were selected. The serum NT-proBNP and UA levels of patients with different cardiac function grades and prognosis were compared, and the correlation was analyzed. The ROC curve was drawn to obtain the predictive value and cut-off value of the observation indicators for prognosis. 【Results】Serum NT-proBNP and UA levels increased with the increase of cardiac function classification, and there was a significant difference between the two groups (P<0.05). The correlation analysis showed that NT-proBNP and UA levels were positively correlated with cardiac function classification (rNT-proBNP=0.143, P=0.006<0.05; rUA=0.115,P=0.026<0.05). After treatment, the levels of NT-proBNP and UA in the poor prognosis group and the good prognosis group were significantly lower than those before treatment, while the levels of NT-proBNP and UA in the poor prognosis group were significantly higher than those in the good prognosis group before and after treatment, with statistical significance (P<0.05). The ROC curve of NT-proBNP predicting poor prognosis showed that the sensitivity and specificity were the highest when NT-proBNP level was 10 850 pg/mL, 73.4% and 72.0% respectively. The ROC curve of UA predicting poor prognosis showed that the sensitivity and specificity were the highest(60.3% and 64.1% respectively) when UA was 436.4 umol/L. 【Conclusion】The higher the grade of cardiac function in elderly patients with chronic heart failure, the higher the serum NT-proBNP and UA levels, the worse the prognosis of patients. Both of them have certain guiding role in judging the prognosis of patients.
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Received: 28 September 2017
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(5): 990-991. |
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2019, Vol. 36 
