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| Effects of Different Dialysis Modes Combined with Low Molecular Weight Heparin on Hemodynamics and Cerebral Hemorrhage in Patients with End Stage Renal Disease |
| WU Sheng-kai, ZENG Bin |
| The Second People's Hospital of Shantou,Shantou, Guangdong province, 515000 |
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Abstract Objective To explore the effects of different dialysis modes combined with low molecular weight heparin on hemodynamics and cerebral hemorrhage in patients with end-stage renal disease (ESRD). Methods According to the different dialysis modes, a total of 96 patients with ESRD were divided into the intermittent dialysis group (group A,n=48) and the continuous dialysis group (group B,n=48).The changes of cardiac function, hemodynamic parameters and related factors, and the occurrence of adverse events during treatment were compared between the two groups. Results There were no significant differences in mean blood pressure, cardiac output, cardiac index, stroke volume, stroke index and intracranial pressure between the two groups before treatment (P>0.05). Compared to before treatment, the variation of stroke volume in group A was higher than that in group B (P<0.05). After dialysis, the level of endothelin-1 (ET-1) in group B was significantly higher than that in group A (P<0.05). There were no significant differences in interleukin-6 (IL-6), thiobarbituric acid reactant (TBARS) and B-type natriuretic peptide(BNP) between the two groups(P>0.05). No significant differences were shown in the incidence of cerebral hemorrhage, cerebral infarction and severe infection between the two groups (P>0.05). Conclusion Intermittent and continuous hemodialysis combined with low molecular weight heparin have no significant difference in hemodynamics and cerebral hemorrhage in patients with ESRD, so it can be flexibly selected according to the specific situation in clinic.
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Received: 05 December 2018
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2019, Vol. 36 
