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| Analysis of Correlation between Serum lncRNA H19 Ex-pression and Postoperative Chemotherapy Effect in Patients with Colorectal Cancer |
| DENG Ling-hui, JIN Jian-hua, LU Wen-bin, et al |
| Department of Oncology, Changzhou Wujin People's Hospital,Changzhou, Jiangsu 213017 |
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Abstract Objective To investigate the correlation between the expression of serum long-chain non-coding RNA (lncRNA) H19 and prognosis in patients with colorectal cancer.Methods Eighty-six patients with colorectal cancer who underwent radical operation and adjuvant chemotherapy in our hospital from January 2013 to December 2015 were selected as the study subjects (observation group). 90 volunteers who underwent physical examination in our hospital during the same period were selected as the control group. The expression level of lncRNA H19 in serum of the two groups was detected by qRT-PCR, and the correlation between the expression level of lncRNA H19 in serum of the observation group and the effect of chemotherapy was analyzed. Results The results of qRT-PCR showed that the level of serum lncRNA H19 in the observation group was (1.63±0.35) significantly higher than that in the control group (1.00 ± 0.11), and the difference was statistically significant (t = 16.259,P<0.01). The critical value 2.03 was set as the median level of serum lncRNA H19 expression in the observation group, and the patients were divided into two groups: high expression group and low expression group, 43 cases in each group. The maximum diameter, low differentiation, lymph node metastasis, invasion of serosa, the proportion of stage Ⅲ~Ⅳ and preoperative CEA level in the high expression group were significantly higher than those in the low expression group (P<0.05). There was no significant difference in the incidence of gastrointestinal discomfort, bone marrow sup-pression, liver and kidney dysfunction, neurotoxicity and mucositis between the high and low expression groups after chemotherapy (P>0.05). The median total survival time (OS) and progression-free survival (PFS) in the high-expression group were 33.6 months and 22.9 months respectively, which were significantly lower than those in the low-expression group (55.8 months and 43.3 months), with statistical significance (P<0.05).Conclusion The survival of patients with high expression of serum lncRNA H19 in colorectal cancer is poor, and the sensitivity of post-operative chemotherapy is lower, but there is no significant correlation with chemotherapy tolerance.
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Received: 04 January 2019
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2019, Vol. 36 
