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| Effect of Arthroscopic Combined with Rehabilitation Braces on Knee Osteoarthritis and its Effect on the Levels of NO, IL-6, MMP-3 and VEGF |
| WU Yang, ZHANG Bing, JIAO Longbing, et al |
| Department of Orthopaedics, Beijing Heping Li Hospital,Beijing,100013,China |
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Abstract Objective To investigate the clinical effect of arthroscopy combined with rehabilitation support in the treatment of knee osteoarthritis (KOA) and its effect on inflammatory factors.Methods Eighty-six cases of KOA from October 2015 to August 2017 were divided into observation group (n=43) and control group (n=43). The control group was treated by arthroscopy alone, while the observation group was treated with rehabilitation support on the basis of the control group. The clinical efficacy and visual analogue score (VAS), Lysholm knee function score, KOA symptom and sign score, serum nitric oxide (NO), interleukin-6 (IL-6) were compared between the two groups before and after treatment. Changes of matrix metalloprotein 3 (MMP-3) and vascular endothelial growth factor (VEGF) levels.Results The total effective rate of the observation group was 90.7% (39/43), which was significantly higher than that of the control group 72.1% (31/43) (χ2=4.914,P=0.048). After treatment, VAS pain score, Lysholm knee function score and KOA symptom and sign score were significantly improved in both groups, and the effect was more obvious in the observation group (P<0.05). After treatment, the levels of serum NO,IL-6,MMP-3 and VEGF in the two groups were significantly lower than those before treatment, and the levels of each index in the observation group were significantly lower than those in the control group (P<0.05).Conclusion Arthroscopy combined with rehabilitation support is effective in the treatment of KOA, which can promote the recovery of knee joint function, relieve pain symptoms, and inhibit the expression of inflammatory factors, which is worth popularizing in clinic.
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Received: 22 March 2018
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2019, Vol. 36 
