|
|
|
| Expression of E-cadherin and Snail in Prostate Cancer and Its Association with Postoperative Biochemical Recurrence |
| LI Gang, ZHU Yang-ting, LI Ning, et al |
| Department of Urology, Dongying Branch of Qilu Hospital of Shandong University, Dongying, Shandong, 257000 China |
|
|
|
|
Abstract 【Objective】 To investigate the expression of E-cadherin and transcription factor Snail in prostate cancer and its clinical significance. 【Methods】 From January 2005 to December 2006, 54 cases of prostate cancer (prostate cancer group) were collected, and 48 cases of benign prostatic hyperplasias (benign prostatic hyperplasia group) were also collected. Immunohistochemistry was used to detect the expression of E-cadherin and Snail protein. The relationship between biochemical recurrence time and expression of E-cadherin and Snail protein in prostate cancer patients was analyzed by Kaplan-Meier method. 【Results】 The positive expression rate of E-cadherin in prostate cancer group (37.04%,20/54) was significantly lower than that in benign prostatic hyperplasia group (83.33%,40/48,P<0.05), while the positive expression rate of Snail in prostate cancer group (62.96%,34/54) was significantly higher than that in benign prostatic hyperplasia group (22.92%,11/48) (P<0.05). The expression of E-cadherin and Snail in prostate cancer tissues was associated with TNM stage, histological differentiation, lymph node metastasis and distant metastasis (P<0.05). The expression of E-cadherin in prostate cancer tissues was negatively correlated with Snail expression (rs=-0.762,P<0.05). Kaplan-Meier analysis showed that biochemical recurrence-free survival in the E-cadherin positive group was significantly higher than that in the E-cadherin negative group (P<0.05), and biochemical recurrence-free survival in the Snail negative group was significantly higher than that in the Snail positive group (P<0.05). 【Conclusion】 The expression of E-cadherin protein is low, while the expression of Snail protein is high in prostate cancer tissues. The expression levels of E-cadherin and Snail are related to occurrence, development and prognosis of prostate cancer.
|
|
Received: 12 June 2017
|
|
|
|
|
|
[1] 邵鹏飞, 殷长军, 李杰,等. 腹腔镜下前列腺癌根治术治疗高危前列腺癌的临床效果分析[J].中华外科杂志, 2015, 53(11):847-851.
[2] 叶定伟, 朱耀. 中国前列腺癌的流行病学概述和启示[J].中华外科杂志, 2015, 53(4):249-252.
[3] 胡四龙, 许晓平, 朱耀,等. ~(99m)Tc标记PSMA小分子抑制剂靶向前列腺癌分子影像初步临床研究[J].中国癌症杂志, 2016, 26(7):608-615.
[4] 阳宁, 王玲, 陈仙,等. 埃兹蛋白(ezrin)基因沉默抑制人前列腺癌PC-3细胞增殖和侵袭[J].细胞与分子免疫学杂志, 2016, 32(6):821-824.
[5] 李汉忠, 张玉石. 2016年前列腺癌诊治热点回顾[J].中华外科杂志, 2017, 55(1):59-62.
[6] 吴天山, 郭飞. 细胞核Snail因子在胰腺癌上皮-间质转化中的作用[J].中国普通外科杂志, 2015, 24(3):426-429.
[7] 孙菊杰, 魏玲, 张德贤,等. 非小细胞肺癌中Snail、HIF-1α和E-cadherin表达的临床意义及相关性[J].肿瘤防治研究, 2015, 42(1):37-40.
[8] 俞岚, 周蕾,武世伍,等. 上皮性卵巢癌中CD133与EMT相关因子表达的关系[J].南方医科大学学报, 2015,15(9):1297-1302. |
|
|
|
2019, Vol. 36 
