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| Safety and Efficacy of Levosulpiride, Domperidone and Metoclopramide in the Treatment of Functional Dyspepsia |
| WEI Tie-jun, ZHANG Heng, GUO Yi-jing, et al |
| Department of Digestive Medicine, the SunSimiao Hospital, Beijing University of Traditional Chinese Medicine,Tongchuan 727000 |
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Abstract 【Objective】 To evaluate and compare the safety and clinical efficacy of levosulpiride, domperidone and metoclopramide in the treatment of functional dyspepsia.【Methods】 One hundred and fifty patients with functional dyspepsia from June 2014 to March 2015 were randomly divided into three groups with 50 cases in each group. The three groups were treated with levosulpiride, domperidone and metoclopramide respectively. The degree of functional dyspepsia before and after treatment was evaluated by Leeds indigestion questionnaire and Likert five-point scale. 【Results】 143 of 150 patients (50 in the levosulpiride group, 45 in the domperidone group and 48 in the metoclopramide group) completed the test successfully. All three drugs can improve patients' symptoms of functional dyspepsia to varying degrees. However, the overall improvement of dyspepsia in the levosulpiride group was significantly higher than that in the other two groups (P<0.05), and the incidence of adverse reactions (including nausea, headache, diarrhea, etc.) was the lowest in the levosulpiride group.【Conclusion】 Levosulpiride has higher safety and efficacy than domperidone and metoclopramide in the treatment of functional dyspepsia.
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Received: 18 April 2017
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2018, Vol. 35 
