Abstract:【Objective】 To explore the application effect of full-cycle rehabilitation nursing path in patients undergoing surgery for Schatzker type Ⅳ-Ⅵ tibial plateau fractures. 【Methods】 A total of 88 patients who underwent surgery for Schatzker type Ⅳ-Ⅵ tibial plateau fractures admitted to our hospital from January to December 2024 were selected and divided into an observation group(intervened with full-cycle rehabilitation nursing path) and a control group(intervened with routine nursing) using the random number table method, with 44 cases in each group. The rehabilitation status, knee joint function score, joint range of motion, pain degree, swelling score and quality of life were compared between the two groups. 【Results】 Three months after the intervention, the length of hospital stay, fracture healing time and full weight-bearing time of the observation group were shorter than those of the control group(P<0.05); the Rasmussen knee function score and Hospital for Special Surgery(HSS) knee function score of the observation group were higher than those of the control group(P<0.05); the flexion angle of the observation group was larger than that of the control group(P<0.05), and the extension limitation angle was smaller than that of the control group(P<0.05). The Visual Analogue Scale(VAS) score and swelling score of the observation group were lower than those of the control group(P<0.05). At 1 month and 3 months after the intervention, the Knee Injury and Osteoarthritis Outcome Score(KOOS) of the observation group was higher than that of the control group(P<0.05). 【Conclusion】 The full-cycle rehabilitation nursing path can effectively promote the postoperative knee joint function recovery of patients with Schatzker type Ⅳ-Ⅵ tibial plateau fractures, relieve pain and improve quality of life, which is worthy of clinical promotion and application.