支气管动脉化疗栓塞术联合<sup>125</sup>I放射性粒子植入术治疗非小细胞肺癌的疗效

doi:10.3969/j.issn.1671-7171.2025.12.023

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摘要 【目的】探讨支气管动脉化疗栓塞术(BACE)联合¹²⁵I放射性粒子植入术治疗非小细胞肺癌(NSCLC)的疗效。【方法】82例NSCLC患者随机分成对照组(吉西他滨联合顺铂化疗)和观察组(BACE联合¹²⁵I放射性粒子植入术治疗),每组41例。比较两组临床疗效,治疗前后肿瘤直径、肺功能指标、视觉模拟评分法(VAS)评分、衰弱评分及不良反应发生情况。【结果】观察组临床有效率(80.49%)高于对照组(51.22%)(P<0.05)。治疗后,观察组的肿瘤直径、VAS评分、衰弱评分均低于对照组(P<0.05);观察组用力肺活量、第1秒用力呼气容积、最大通气量均高于对照组(P<0.05)。观察组患者恶心、呕吐,脱发、Ⅰ~Ⅳ度骨髓抑制发生率均低于对照组(P<0.05)。【结论】BACE联合¹²⁵I放射性粒子植入术治疗NSCLC患者,可显著提高临床疗效,缩小肿瘤体积,改善肺功能,缓解癌性疼痛与衰弱状态,减少不良反应。

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关键词 ：癌,非小细胞肺, 支气管动脉, 碘放射性同位素, 化学栓塞,治疗性, 治疗结果

Abstract：【Objective】 To investigate the efficacy of bronchial artery chemoembolization (BACE) combined with ¹²⁵I seed implantation in the treatment of non-small cell lung cancer (NSCLC). 【Methods】 A total of 82 NSCLC patients were randomly divided into a control group (gemcitabine plus cisplatin chemotherapy) and an observation group (BACE combined with ¹²⁵I seed implantation), with 41 cases in each group. Clinical efficacy, tumor diameter, pulmonary function indices, cancer pain scores, frailty scores, and adverse reactions were compared between the two groups before and after treatment. 【Results】 The clinical response rate in the observation group (80.49%) was higher than that in the control group (51.22%) (P<0.05). After treatment, tumor diameter, cancer pain scores, and frailty scores in the observation group were lower than those in the control group (P<0.05). Forced vital capacity, forced expiratory volume in 1 second, and maximal voluntary ventilation were all higher in the observation group than in the control group (P<0.05). The incidences of nausea, vomiting, alopecia, and grade Ⅰ-Ⅳ myelosuppression in the observation group were lower those in the group group (P<0.05). 【Conclusion】 BACE combined with ¹²⁵I seed implantation can significantly improve the clinical efficacy in NSCLC patients, reduce tumor size, improve pulmonary function, alleviate cancer pain and frailty, and reduce adverse reactions.

Key words： Carcinoma, Non-Small-Cell Lung Bronchial Arteries Iodine Radioisotopes Chemoembolization, Therapeutic Treatment Outcome

收稿日期: 2025-06-13

中图分类号:

R734.2

引用本文:

王彤, 张延超, 魏乐群, 王朝阳, 牛焕章. 支气管动脉化疗栓塞术联合¹²⁵I放射性粒子植入术治疗非小细胞肺癌的疗效[J]. 医学临床研究, 2025, 42(12): 2097-2099.
WANG Tong, ZHANG Yanchao, WEI Lequn, et al. Efficacy of Bronchial Artery Chemoembolization Combined with ¹²⁵I Seed Implantation in the Treatment of Non-Small Cell Lung Cancer. JOURNAL OF CLINICAL RESEARCH, 2025, 42(12): 2097-2099.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.12.023 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I12/2097

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