Diagnostic Value of Cranial MRI Combined with Transcranial Sonography of the Substantia Nigra in Differentiating Parkinson's Disease from Vascular Parkinsonism
ZHENG Shiru, REN Yafang, WANG Chunhui, et al
Department of Neurology, Zhengzhou People's Hospital, Zhengzhou Henan 450000
Abstract：【Objective】 To investigate the diagnostic value of cranial magnetic resonance imaging (MRI) combined with transcranial sonography (TCS) of the substantia nigra in differentiating Parkinson's disease (PD) from vascular parkinsonism (VPS).【Methods】 Thirty-eight PD patients (the PD group), 30 VPS patients (the VPS group), and 37 healthy volunteers (the control group) were enrolled. Cranial MRI and TCS findings were compared among the three groups. Receiver operating characteristic (ROC) curves were used to analyze the diagnostic value of MRI and TCS for PD and VPS.【Results】 The width of the pars compacta of the substantia nigra (WPCSN) and the WPCSN/midbrain diameter ratio were significantly lower in both the PD and VPS groups compared to the control group, with the PD group showing lower values than the VPS group (all P<0.05). The bilateral hyperechogenic areas of the substantia nigra, the total hyperechogenic area, and the ratio of hyperechogenic area to total midbrain area (S/M) in the PD and VPS groups were significantly higher than those in the control group, and they were higher in the PD group than in the VPS group (all P<0.05). Among the individual MRI and TCS parameters, the bilateral S/M showed the highest diagnostic value for differentiating PD from VPS. Combined MRI and TCS assessment demonstrated higher diagnostic performance than any single MRI or TCS parameter.【Conclusion】 The combined application of both cranial MRI and TCS can significantly improve the diagnostic efficiency in distinguishing PD from VPS, providing a valuable and noninvasive imaging basis for accurate clinical differentiation.
郑世茹, 任雅芳, 王春慧, 刘冰, 范文斐, 张淑玲. 颅脑MRI联合经颅黑质超声检查对帕金森病与血管性帕金森综合征的鉴别诊断价值[J]. 医学临床研究, 2025, 42(12): 2032-2034.
ZHENG Shiru, REN Yafang, WANG Chunhui, et al. Diagnostic Value of Cranial MRI Combined with Transcranial Sonography of the Substantia Nigra in Differentiating Parkinson's Disease from Vascular Parkinsonism. JOURNAL OF CLINICAL RESEARCH, 2025, 42(12): 2032-2034.
2025, Vol. 42 
