Effect of Initiation Timing of Continuous Renal Replacement Therapy on 28-Day Cumulative Survival Rate of Patients with Sepsis-induced Acute Kidney Injury
Abstract：【Objective】 To explore the impact of the initiation timing of Continuous Renal Replacement Therapy(CRRT) on the 28-day cumulative survival rate of patients with Sepsis-Induced Acute Kidney Injury(SI-AKI). 【Methods】A total of 144 SI-AKI patients admitted to the ICU of our hospital were randomly divided into an early CRRT group and a control group, with 72 patients in each group. Clinical data, treatment schemes, and the 28-day cumulative survival rates of the two groups were compared. The changes in inflammatory and renal function indicators before and after treatment in both groups were compared as well. The impact of early CRRT on the 28-day cumulative survival rate was analyzed. 【Results】Patients in the early CRRT group had a longer non-mechanical ventilation time than those in the control group(P<0.05).Before treatment, there were no significant differences in any indicators between the two groups(P>0.05). After treatment, all inflammatory indicators including procalcitonin(PCT), C-reactive protein(CRP), WBC, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), and renal function indicators such as serum creatinine(Scr), blood urea nitrogen(BUN), and Lactate, significantly decreased compared to before treatment(P<0.05), and the reductions in PCT, CRP, IL-6, Scr, BUN in the early CRRT group were significantly greater than those in the control group(P<0.05).Kaplan-Meier survival analysis indicated that the 28-day cumulative survival rate of patients in the early CRRT group was significantly higher than that of the control group (P<0.05). 【Conclusion】Early initiation of CRRT can improve the 28-day cumulative survival rate of SI-AKI patients and clinical outcomes.
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2024, Vol. 41 
