Abstract：【Objective】 To explore the therapeutic effect of topiramate combined with Chuanxiong Qingnao Granules and Zhengtian Pills on children with migraine. 【Methods】 A total of 84 children with migraine admitted to two hospitals were randomly divided into two groups,with 42 cases in each group. The control group was treated with topiramate combined with Zhengtian Pills,while the observation group was treated with Chuanxiong Qingnao Granules in addition to the control group. The clinical symptoms and efficacy,the abnormal rate of Transcranial Doppler ultrasound (TCD) and the score of Pediatric Quality of Life Scale 4.0 (PedsQLTM 4.0) were compared between the two groups before treatment,2 months after treatment and 6 months after treatment,and the drug safety was recorded. 【Results】 The degree,frequency,and duration of migraine in both groups were lower than before treatment 2 months and 6 months after treatment (P<0.05). The degree,frequency,and duration of migraine in both groups were lower than 2 months after treatment (P<0.05),and the observation group was lower than the control group (P<0.05). The total effective rate of the observation group was higher than that of the control group (P<0.05). The abnormal rates of TCD at 2 months and 6 months after treatment in both groups were lower than before treatment (P<0.05). The abnormal rates of TCD at 6 months after treatment were lower than those at 2 months after treatment (P<0.05). The abnormal rates of TCD in the observation group were lower than those in the control group at 6 months after treatment (P<0.05). The PedsQLTM 4.0 scores of both groups were higher than before treatment at 2 months and 6 months after treatment (P<0.05). The PedsQLTM 4.0 scores of the observation group were higher than those of the control group at 6 months after treatment (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Topiramate combined with Chuanxiong Qingnao Granules and Zhengtian Pills can alleviate symptoms,enhance efficacy,improve cerebral blood flow status,improve quality of life,and have good safety in treating children with migraine.
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2023, Vol. 40 
