Abstract：【Objective】To investigate the predictive effect of soluble myeloid cell trigger receptor-1 (sTREM-1) combined with Clara cell secretory protein (CC16) on poor prognosis in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). 【Methods】A total of 206 patients with COPD treated in our hospital from February 2019 to March 2020 was selected, including 108 patients with acute exacerbation of COPD (AECOPD) (group A) and 98 patients with stable COPD (group B). In addition, 95 healthy volunteers (Group C) who underwent physical examination in our hospital at the same time were selected. The levels of serum sTREM-1 and CC16 in the three groups were compared; The incidence of poor prognosis in AECOPD patients was counted and divided into poor prognosis group and good prognosis group according to the prognosis; The clinical data of poor prognosis group and good prognosis group were compared; Logistic regression analysis was used to analyze the prognostic factors of AECOPD patients; The receiver operating characteristic curve (ROC) was made to analyze the predictive efficacy of sTREM-1 combined with CC16 in the poor prognosis of elderly AECOPD patients. 【Results】 The level of sTREM-1 in the group A and the group B was significantly higher than that in then group C (P<0.05), and the level of CC16 was significantly lower than that in the group C (P<0.05); The level of sTREM-1 in the group A was significantly higher than that in the group B (P<0.05), and the level of CC16 was significantly lower than that in the group B (P<0.05); The incidence of poor prognosis in AECOPD patients was 25.93% (28/108); The mechanical ventilation time, procalcitonin (PCT), C-reactive protein (CRP) and sTREM-1 levels in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05), while the vital capacity (FVC), forced expiratory volume in the first second (FEV1) and CC16 levels in the poor prognosis group were significantly lower than those in the good prognosis group (P<0.05); Logistic regression showed that CRP, sTREM-1 and CC16 were the influencing factors of poor prognosis in patients with AECOPD (P<0.05); ROC analysis showed that the best cutoff points for predicting the poor prognosis of elderly AECOPD patients by the levels of sTREM-1 and CC16 were 161.25 ng/L and 65.83μg/L , respectively; The specificity of the combination of sTREM-1 and CC16 was 96.25%, which was significantly higher than that of serum sTREM-1 and CC16 alone. The area under the curve (AUC) of the combination of sTREM-1 and CC16 in predicting the poor prognosis of elderly AECOPD patients was 0.923, which was higher than that of serum sTREM-1 and CC16 alone (P<0.05). 【Conclusion】sTREM-1 combined with CC16 is effective in predicting the poor prognosis of elderly AECOPD patients, and can be used to predict the poor prognosis of elderly AECOPD patients.
魏丹, 陈娟. sTREM-1联合CC16对老年AECOPD患者预后不良的预测效能[J]. 医学临床研究, 2021, 38(10): 1504-1507.
WEI Dan, CHEN Juan. Prognostic Value of sTREM-1 Combined with CC16 in Elderly Patients with Chronic Obstructive Pulmonary Disease. JOURNAL OF CLINICAL RESEARCH, 2021, 38(10): 1504-1507.
2021, Vol. 38 
