Abstract:【Objective】 To investigate the correlation between serum uric acid and mild gastroenteritis with benign convulsion【 Methods】A total of 320 children with acute gastroenteritis (age) treated in Hunan children's Hospital from March 2020 to March 2021 was divided into mild gastroenteritis with benign convulsion (bice group,n=60) and simple age group (n=260); In addition, children with simple febrile convulsion (FC) treated in our hospital in the same period (FC group,n=60) were selected. The serum uric acid (SUA) levels of children in the three groups before treatment were compared, and the serum uric acid levels of children in the age group and the BICE group before and after treatment were compared under different degrees of dehydration. 【Results】 Before treatment, the SUA level in the BICE group was significantly higher than that in the FC group and the age group, and that in the age group was significantly higher than that in the FC group. There was significant difference among the three groups (F=8.713, P<0.05). Before treatment, the SUA level of children with severe dehydration in the age group was significantly higher than that of children with mild dehydration, moderate dehydration and no dehydration, children with moderate dehydration were higher than those with mild dehydration and no dehydration, and children with mild dehydration were higher than those without dehydration (P<0.05); There was no significant difference in SUA levels between the BICE groups with different degrees of dehydration (P>0.05); There was no significant difference in SUA level between the BICE group and the pre-treatment group (P>0.05); The SUA level of children without dehydration and mild dehydration in the BICE group was significantly higher than that in the age group, and the SUA level of children with severe dehydration was significantly lower than that in the age group (P<0.05); There was no significant difference in SUA level between the BICE group and the age group (P>0.05). 【Conclusion】 The results of this study show that the level of serum uric acid in children with BICE is significantly higher than that in children with age alone, and is not affected by the degree of dehydration. This specificity suggests that there is a correlation between serum uric acid and the occurrence of BICE.
王哲, 游洁玉. 血清尿酸与轻度胃肠炎并良性惊厥的相关性分析[J]. 医学临床研究, 2021, 38(9): 1304-1306.
WANG Zhe, YOU Jie-yu. Correlation between Serum Uric Acid and Mild Gastroenteritis Complicated with Benign Convulsion. JOURNAL OF CLINICAL RESEARCH, 2021, 38(9): 1304-1306.
[1] WIELGOS K,SETKOWICZ W,PASTERNAK G,et al.Management of acute gastroenteritis in children[J].Pol Merkur Lekarski,2019,47(278):76-79. [2] 彭陈岑,黄建萍.小儿热性惊厥发病相关因素的研究进展[J].医学综述,2009,15(21):3270-3273. [3] YA B L,LIU Q,LI H F,et al.Uric acid protects against focal cerebral ischemia/reperfusion-induced oxidative stress via activating Nrf2 and regulating neurotrophic factor expression[J].Oxid Med Cell Longev,2018,2018:6069150. [4] LAKATOS R K,DOBOLY I,KOV CS Z.Uric acid and allopurinol aggravate absence epileptic activity in Wistar Albino Glaxo Rijswijk rats[J].Brain Res,2018,1686:1-9. [5] 周江.小儿腹泻病治疗新进展[J].临床医药文献电子杂志,2020,7(1):197-198. [6] 张彦博,张滟,张学琴.轻度胃肠炎伴婴幼儿良性惊厥患儿血清一氧化氮水平、一氧化氮合酶活性、白细胞介素及其受体水平的变化及意义[J].广西医学,2020,42(18):2357-2360. [7] TIAN T,WANG Z,ZHANG J.Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies[J].Oxid Med Cell Longev,2017,2017:4535194. [8] CHONG W C,SHASTRI M D,Eri R.Endoplasmic reticulum stress and oxidative stress: a vicious nexus implicated in bowel disease pathophysiology[J].Int J Mol Sci,2017,18(4):771. [9] 朱乾乾. 轻型胃肠炎伴婴幼儿良性惊厥的临床特点研究[D].吉林:吉林大学,2016. [10] LI L,WANG J,CHEN Z.Colorimetric determination of uric acid based on the suppression of oxidative etching of silver nanoparticles by chloroauric acid[J].Mikrochim Acta,2019,187(1):18.