[1] Kanemaki M, Sanchez-Diaz A, Gambus A, et al . Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo[J]. Nature, 2003, 423(6941): 720-724. [2] Kubota Y, Takase Y, Komori Y, et al . A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication[J]. Genes Dev, 2003, 17(9): 1141-1152. [3] Kamada K.The GINS complex: structure and function[J]. Subcell Biochem, 2012, 62: 135-156. [4] Labib K, Gambus A.A key role for the GINS complex at DNA replication forks[J]. Trends Cell Biol, 2007, 17(6): 271-278. [5] Takayama Y, Kamimura Y, Okawa M, et al . GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast[J]. Genes Dev, 2003, 17(9): 1153-1165. [6] Kamada K, Kubota Y, Arata T, et al . Structure of the human GINS complex and its assembly and functional interface in replication initiation[J]. Nat Struct Mol Biol, 2007, 14(5): 388-396. [7] MacNeill SA. Structure and function of the GINS complex, a key component of the eukaryotic replisome[J]. Biochem J, 2010, 425(3): 489-500. [8] Moyer SE, Lewis PW, Botchan MR.Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase[J]. Proc Natl Acad Sci U S A, 2006, 103(27): 10236-10241. [9] Matsuoka S, Ballif BA, Smogorzewska A, et al . ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage[J]. Science, 2007, 316(5828): 1160-1166. [10] Ilves I, Petojevic T, Pesavento JJ, et al . Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins[J]. Mol Cell, 2010, 37(2): 247-258. [11] Gambus A, van Deursen F, Polychronopoulos D, et al. A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome[J]. EMBO J, 2009, 28(19): 2992-3004. [12] Gambus A, Jones RC, Sanchez-Diaz A, et al . GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks[J]. Nat Cell Biol, 2006, 8(4): 358-366. [13] Bu F, Zhu X, Zhu J, et al . Bioinformatics Analysis Identifies a Novel Role of GINS1 Gene in Colorectal Cancer[J]. Cancer Manag Res, 2020, 12: 11677-11687. [14] Gambus A, Jones RC, Sanchez-Diaz A, et al . GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks[J]. Nat Cell Biol, 2006, 8(4): 358-366. [15] Kamimura Y, Tak YS, Sugino A, et al . Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae[J]. EMBO J, 2001, 20(8): 2097-2107. [16] Kanemaki M, Labib K.Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks[J]. EMBO J, 2006, 25(8): 1753-1763. [17] Gambus A, Jones R C, Sanchez-Diaz A, et al . GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks[J]. Nat Cell Biol, 2006, 8(4): 358-366. [18] Yabuuchi H, Yamada Y, Uchida T, et al . Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins[J]. EMBO J, 2006, 25(19): 4663-4674. [19] Kubota Y, Takase Y, Komori Y, et al . A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication[J]. Genes Dev, 2003, 17(9): 1141-1152. [20] Yabuuchi H, Yamada Y, Uchida T, et al . Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins[J]. EMBO J, 2006, 25(19): 4663-4674. [21] Kubota Y, Takase Y, Komori Y, et al . A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication[J]. Genes Dev, 2003, 17(9): 1141-1152. [22] Cottineau J, Kottemann MC, Lach FP, et al . Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency[J]. J Clin Invest, 2017, 127(5): 1991-2006. [23] Ouyang F, Liu J, Xia M, et al . GINS2 is a novel prognostic biomarker and promotes tumor progression in early-stage cervical cancer[J]. Oncol Rep, 2017, 37(5): 2652-2662. [24] Nakahara I, Miyamoto M, Shibata T, et al . Up-regulation of PSF1 promotes the growth of breast cancer cells[J]. Genes Cells, 2010, 15(10): 1015-1024. [25] Toda H, Seki N, Kurozumi S, et al . RNA-sequence-based microRNA expression signature in breast cancer: tumor-suppressive miR-101-5p regulates molecular pathogenesis[J]. Mol Oncol, 2020, 14(2): 426-446. [26] Tang L, Yu W, Wang Y, et al . Anlotinib inhibits synovial sarcoma by targeting GINS1: a novel downstream target oncogene in progression of synovial sarcoma[J]. Clin Transl Oncol, 2019, 21(12): 1624-1633. [27] Bu F, Zhu X, Zhu J, et al . Bioinformatics Analysis Identifies a Novel Role of GINS1 Gene in Colorectal Cancer[J]. Cancer Manag Res, 2020, 12: 11677-11687. [28] Yan T, Liang W, Jiang E, et al . GINS2 regulates cell proliferation and apoptosis in human epithelial ovarian cancer[J]. Oncol Lett, 2018, 16(2): 2591-2598. [29] Liu X, Sun L, Zhang S, et al . GINS2 facilitates epithelial-to-mesenchymal transition in non-small-cell lung cancer through modulating PI3K/Akt and MEK/ERK signaling[J]. J Cell Physiol, 2020, 235(11): 7747-7756. [30] Peng L, Song Z, Chen D, et al . GINS2 regulates matrix metallopeptidase 9 expression and cancer stem cell property in human triple negative Breast cancer[J]. Biomed Pharmacother, 2016, 84: 1568-1574. [31] Shen YL, Li HZ, Hu YW, et al . Loss of GINS2 inhibits cell proliferation and tumorigenesis in human gliomas[J]. CNS Neurosci Ther, 2019, 25(2): 273-287. [32] Liu C, Wang R, Zhang Y.GINS complex subunit 2 (GINS2) plays a protective role in alcohol-induced brain injury[J]. Artif Cells Nanomed Biotechnol, 2019, 47(1): 1-9. [33] Hokka D, Maniwa Y, Tane S, et al . Psf3 is a prognostic biomarker in lung adenocarcinoma[J]. Lung Cancer, 2013, 79(1): 77-82. [34] Tauchi S, Sakai Y, Fujimoto S, et al . Psf3 is a prognostic biomarker in lung adenocarcinoma: a larger trial using tissue microarrays of 864 consecutive resections[J]. Eur J Cardiothorac Surg, 2016, 50(4): 758-764. [35] Kimura K, Tanaka Y, Tauchi S, et al . Psf3 as a possible biomarker of postoperative chemotherapy for patients with early pulmonary adenocarcinoma[J]. Thorac Cancer, 2019, 10(12): 2300-2307. [36] Tane S, Sakai Y, Hokka D, et al . Significant role of Psf3 expression in non-small-cell lung cancer[J]. Cancer Sci, 2015, 106(11): 1625-1634. [37] Sun X, Sui W, Huang M, et al . Partner of Sld five 3: a potential prognostic biomarker for colorectal cancer[J]. Diagn Pathol, 2014, 9: 217. [38] Nagahama Y, Ueno M, Haraguchi N, et al . PSF3 marks malignant colon cancer and has a role in cancer cell proliferation[J]. Biochem Biophys Res Commun, 2010, 392(2): 150-154. [39] Yang R, Liu N, Chen L, et al . LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer[J]. J Exp Clin Cancer Res, 2019, 38(1): 280. [40] Rong Z, Luo Z, Zhang J, et al . GINS complex subunit 4, a prognostic biomarker and reversely mediated by Kruppel-like factor 4, promotes the growth of colorectal cancer[J]. Cancer Sci, 2020, 111(4): 1203-1217. [41] Zhu Z, Yu Z, Rong Z, et al . The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42[J]. Theranostics, 2019, 9(26): 8294-8311.
2021, Vol. 38 
