[1] Alatas F,Alatas O,Metintas M,et al.Diagnostic value of CEA,CA15-3,CA 19-9,CYFRA 21-1,NSE and TSA assay in pleural effusions[J].Lung Cancer,2001,31(1):9-16. [2] Porcel JM,Vives M,Esquerda A,et al.Use of a panel of tumor mark-ers (carcinoembryonic antigen,cancer antigen 125,carbohydrate antigen15-3,and cytokeratin 19 fragments)in pleural fluid for the differential diagnosis of benign and malignant effusions[J].Chest,2004,126(6):1757-1763. [3] Mammas IN,Sourvinos G,Zaravinos A,et al.Vaccination aganist Human papilloma virus(HPV):epidemiological evidence of HPV in nongenital cancer[J].Pathol Oncol Res,2011,17(1):103-119. [4] Fan R, Hou WJ, Zhao YJ, et al. Overexpression of HPV16 E6/E7 mediated HIF-1α upregulation of GLUT1 expression in lung cancer cells[J].Tumour Biol,2016,37(4):4655-4663. [5] Li G,He L,Zhang E,et al. Overexpression of human papillomavirus (HPV) type 16 oncoproteins promotes angiogenesis via enhancing HIF-1α and VEGF expression in non-small cell lung cancer cells[J].Cancer Lett,2011,311(2):160-170. [6] Grosfeld A, Andre J, Hauguel-De Mouzon S, et al. Hypoxia-inducible factor 1 transactivates the human leptin gene promoter[J].J Biol Chem,2002,277(45):42953-42957. [7] Mathupala Sp, Rempel A, pedersen pL. Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type Ⅱ hexokinase gene to hypoxic conditions[J].J Biol Chem,2001,276(46):43407-43412. [8] Sack U, Hoffmann M, Zhao X J, et al. Vascular endothelial growth factor in pleural effusions of different origin[J].Eur Respir J,2005,25(4):600-604. [9] Ziora D,Sielska-Spytek E,Dworniczak S,et al. VEGF (vascular endothelial growth factor) concentration in serum and pleural fluid of patients with pleural malignancy and pleural tuberculosis[J].Pneumonol Alergol Pol,2002,70(9-10):458-467.