Abstract：【Objective】To investigate the changes in biochemical markers between tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) for their significance in making differential diagnosis. 【Methods】A total of 92 pleural effusion cases were collected from January 2012 to January 2016 at our hospital. Among them, there were 52 cases of TPE and 40 cases of MPE. At admission, 5ml of pleural effusions was harvested by pleural biopsy. Routine examination of pleural effusion (white blood cells, lymphocytes, neutrophils, eosinophils, mesothelial / tissue cells, total protein, lactate dehydrogenase, glucose) and cytokines [IL-1β, IL-10, IL-13, IFN-gamma, chemokines interferon inducible protein 10 (IP-10), basic fibroblasts Cell growth factor (bFGF)]were tested. 【Results】The number of white blood cells in pleural effusion was significantly higher in TPE patients than in MPE patients (P<0.05). However, in MPE and TPE patients, the number of pleural effusion lymphocytes, neutrophils, eosinophils, mesothelial, Lactate dehydrogenase (LDH) and glucose were not statistically significant. The levels of IL-1β, IP-10, IL-13 and IFN-γ in tuberculous pleural effusion were significantly higher than those in malignant pleural effusion. The level of bFGF in malignant pleural effusion was significantly higher than that in tuberculous pleural effusion. There were no significant differences in IL-10 levels in both pleural fluids. ROC curve analysis showed that when the optimal thresholds were 5.5 pg/mL for IL-1β, 4005 pg/mL for IP-10, 7.9 pg/mL for IL-13, 100.5 pg/mL for IFN-γ and 2.4 pg/mL for bFGF (P<0.05), which was valuable in the diagnosis of tuberculous and malignant pleural effusion. 【Conclusion】The changes of IL-1β, IP-10, IL-13, IFN-γ and bFGF have important differential diagnostic value in tuberculous and malignant pleural effusion.
张宁;王珂;张霞;. 结核性与恶性胸腔积液相关生化指标变化及鉴别诊断[J]. 医学临床研究, 2017, 34(4): 651-654,657.
ZHANG Ning, WANG Ke, ZHANG Xia. Changes and Differential Diagnosis of Biochemical Markers related to Tuberculous and Malignant Pleural Effusion. JOURNAL OF CLINICAL RESEARCH, 2017, 34(4): 651-654,657.
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2017, Vol. 34 
