不同剂量培哚普利治疗缺血性心力衰竭患者的疗效及对心功能、血清指标的影响

doi:10.3969/j.issn.1671-7171.2025.08.019

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摘要【目的】探讨不同剂量培哚普利治疗缺血性心力衰竭患者的疗效及对心功能、血清指标的影响。【方法】回顾性分析2019年4月至2022年4月在天津市津南区喜康医院和天津市第三中心医院诊治的100例缺血性心力衰竭患者的临床资料,根据患者培哚普利的用药剂量分为大剂量组(采用大剂量培哚普利治疗,n=52)与小剂量组(采用小剂量培哚普利治疗,n=48)。比较两组治疗效果和不良反应发生情况,治疗前后血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、N末端B型利钠肽前体(NT-proBNP)水平及左室射血分数(LVEF)、左心室收缩末内径(LVESD)、左心室舒张末内径(LVEDD)。【结果】大剂量组患者总有效率为94.23%,显著高于小剂量组的79.17%,差异有统计学意义(P<0.05)。治疗后,两组患者血清NGAL、NT-proBNP水平显著低于治疗前,且大剂量组低于小剂量组(P<0.05);治疗后,两组LVEF显著高于治疗前,且大剂量组高于小剂量组,LVESD、LVEDD显著短于治疗前,且大剂量组短于小剂量组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】大剂量培哚普利治疗缺血性心力衰竭患者的疗效较好,可显著改善患者血清NGAL、NT-proBNP水平和心功能。

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	李芙蓉
	喻为人
	皮淑芳

关键词 ：心力衰竭, 培哚普利, 心脏功能试验, 治疗结果

Abstract：【Objective】To investigate the efficacy of different doses of perindopril in the treatment of patients with ischemic heart failure and its effects on cardiac function and serum indicators. 【Methods】The clinical data of 100 patients with ischemic heart failure diagnosed and treated at Tianjin Jinnan District Xikang Hospital from April 2019 to April 2022 were retrospectively analyzed. According to the dosage of perindopril, the patients were divided into a high-dose group (treated with a high dose of perindopril, n=52) and a low-dose group (treated with a low dose of perindopril, n=48). The treatment efficacy, incidence of adverse reactions, serum levels of neutrophil gelatinase-associated lipocalin (NGAL) and N-terminal pro-brain natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), and left ventricular end-diastolic diameter (LVEDD) were compared between the two groups before and after treatment. 【Results】The total effective rate in the high-dose group was 94.23%, significantly higher than that in the low-dose group (79.17%), and the difference was statistically significant (P<0.05). After treatment, the serum levels of NGAL and NT-proBNP in both groups were significantly lower than those before treatment, and the levels in the high-dose group were lower than those in the low-dose group (P<0.05). After treatment, the LVEF in both groups was significantly higher than that before treatment, and it was higher in the high-dose group than in the low-dose group; the LVESD and LVEDD were significantly shorter than those before treatment, and they were shorter in the high-dose group than in the low-dose group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 High-dose perindopril is more effective in treating patients with ischemic heart failure, significantly improving serum levels of NGAL and NT-proBNP, as well as cardiac function.

Key words： Heart Failure Perindopril Heart Function Tests Treatment Outcome

收稿日期: 2024-05-14

中图分类号:

R541.61

引用本文:

李芙蓉, 喻为人, 皮淑芳. 不同剂量培哚普利治疗缺血性心力衰竭患者的疗效及对心功能、血清指标的影响[J]. 医学临床研究, 2025, 42(8): 1360-1362.
LI Furong, YU Weiren, PI Shufang. Efficacy of Different Doses of Perindopril in the Treatment of Patients with Ischemic Heart Failure and its Effects on Cardiac Function and Serum Indicators. JOURNAL OF CLINICAL RESEARCH, 2025, 42(8): 1360-1362.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.08.019 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I8/1360

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