Abstract:【Objective】 To investigate the clinical efficacy of Zhishen Tiaosui acupuncture combined with Fuyang moxibustion in treating post-stroke cognitive impairment (PSCI).【Methods】 A total of 106 patients with PSCI were randomly divided into the control group (treated with conventional acupuncture) and the observation group (treated with Zhishen Tiaosui acupuncture combined with Fuyang moxibustion), with 53 patients in each group. Neurological function, cognitive function, daily living ability, oxidative stress and metabolic indicators, and neuroprotective markers were compared before and after treatment.【Results】 After treatment, the observation group had significantly lower National Institutes of Health Stroke Scale (NIHSS) scores and significantly higher Neurobehavioral Cognitive Status Examination (NCSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living (ADL), and Barthel Index scores compared to the control group (P<0.05). The levels of homocysteine (Hcy), cystatin C (cys C), malondialdehyde (MDA), and neuron-specific enolase (NSE) were significantly lower in the observation group, while glutathione (GSH) and brain-derived neurotrophic factor (BDNF) levels were significantly higher than in the control group (P<0.05).【Conclusion】 Zhishen Tiaosui acupuncture combined with Fuyang moxibustion can significantly improve cognitive function, enhance daily living abilities, and optimize oxidative stress response and metabolic function in patients with PSCI.