Abstract：【Objective】To investigate the effect of different semen optimization methods on the clinical outcome of intrauterine insemination by AIH.【Methods】A total of 124 patients with IUI admitted to our hospital from January 2020 to December 2023 were selected and divided into the upstream group (n=40) and the density gradient centrifuge group (n=84) according to different semen optimization treatment methods. The pregnancy status and pregnancy outcome of the two groups were compared.【Results】Of 124 IUI patients, 20 were pregnant (16.13%). There were 7 clinical pregnancies (17.50%) in the upstream group and 13 clinical pregnancies (15.48%) in the density gradient centrifuge group. There was no biochemical pregnancy between the two groups. There was no statistical significance in clinical pregnancy between the two groups (P>0.05). In the upstream group of 7 clinical pregnancies, there were 2 live births (28.57%) and 5 abortions (71.43%), including 4 abortions caused by fetal stop and 1 abortion caused by ectopic pregnancy. Among the 13 clinical pregnancies in the density gradient centrifuge group, 11 cases (84.62%) of live births and 2 cases (15.38%) of miscarriages were caused by fetal stop. The live birth rate of the density gradient centrifugation group was significantly higher than that of the upstream group, and the abortion rate was significantly lower than that of the upstream group, with statistical significance (P<0.05).【Conclusion】There is no difference between upstream method and density gradient centrifugation method on the pregnancy rate of intrauterine insemination by AIH. The live birth rate of density gradient centrifugation method is higher than upstream method, and the abortion rate is lower than upstream method. When intrauterine insemination is performed, different semen optimization methods should be selected according to the specific conditions of patients.
王娟. 不同精液优化处理方式对夫精宫腔内人工授精临床妊娠结局的影响[J]. 医学临床研究, 2024, 41(11): 1743-1745.
WANG Juan. Effect of Different Semen Optimization Methods on Clinical Pregnancy Outcome of Intrauterine Insemination by AIH. JOURNAL OF CLINICAL RESEARCH, 2024, 41(11): 1743-1745.
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2024, Vol. 41 
