不同亚型幼年特发性关节炎患儿免疫功能指标及关节炎抗体比较

doi:10.3969/j.issn.1671-7171.2026.03.024

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1256 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 【目的】探讨不同亚型幼年特发性关节炎患儿免疫功能指标及关节炎抗体差异。【方法】选择2019年10月至2024年10月苏州市相城人民医院收治的104例幼年特发性关节炎患儿,根据患儿特发性关节炎类型分为全身型组(n=38)、多关节炎型组(n=24)、少关节炎型组(n=42)。比较不同组别患儿的免疫功能指标[淋巴细胞亚群(CD3、CD4、CD8、CD4/CD8)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)及补体C3、C4]、关节炎抗体[抗角蛋白抗体(AKA)、抗核周因子(APF)、抗环瓜氨酸肽抗体(ACPA)、类风湿因子(RF)-IgG]。【结果】全身型组CD3、CD4水平及CD4/CD8值均显著高于多关节炎型组及少关节炎型组(P<0.05),CD8水平显著低于多关节炎型组及少关节炎型组(P<0.05);多关节炎型组CD8水平显著低于少关节炎型组(P<0.05)。全身型组IgG、IgM、IgA水平显著高于少关节炎型组(P<0.05),C3、C4水平显著高于多关节炎型组及少关节炎型组(P<0.05);多关节炎型组IgG、IgM、IgA水平显著高于少关节炎型组(P<0.05)。全身型组AKA、ACPA、APF、RF-IgG阳性率均低于多关节炎型组,差异有统计学意义(P<0.05);多关节炎型组AKA、ACPA、APF阳性率均高于少关节炎型组,差异有统计学意义(P<0.05)。【结论】不同亚型幼年特发性关节炎患儿免疫功能紊乱程度及关节炎抗体阳性率存在显著差异,可能与其发病机制不同有关。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	王莹
	齐亚茹

关键词 ：关节炎, 青少年, 免疫测定, 抗体

Abstract：【Objective】 To explore the differences in immunity and arthritis antibodies in children with different subtypes of juvenile idiopathic arthritis. 【Methods】 A total of 104 children with juvenile idiopathic arthritis admitted to our clinic from October 2019 to October 2024 were selected and divided into three groups according to the type of idiopathic arthritis: systemic type group (n=38), polyarticular type group (n=24), and oligoarticular type group (n=42). Immune function indicators [lymphocyte subsets (CD3, CD4, CD8, CD4/CD8), immunoglobulin M (IgM), immunoglobulin G (IgG), immunoglobulin A (IgA), and complement C3, C4] and arthritis antibodies [anti-keratin antibody (AKA), anti-perinuclear factor (APF), anti-cyclic citrullinated peptide antibody (ACPA), rheumatoid factor (RF)-IgG] were compared among different groups. 【Results】 The levels of CD3, CD4 and the ratio of CD4/CD8 in the systemic type group were significantly higher than those in the polyarticular type group and oligoarticular type group (P<0.05), and the level of CD8 was significantly lower than that in the polyarticular type group and oligoarticular type group (P<0.05); the level of CD8 in the polyarticular type group was significantly lower than that in the oligoarticular type group (P<0.05). The levels of IgG, IgM and IgA in the systemic type group were significantly higher than those in the oligoarticular type group (P<0.05), and the levels of C3 and C4 were significantly higher than those in the polyarticular type group and oligoarticular type group (P<0.05); the levels of IgG, IgM and IgA in the polyarticular type group were significantly higher than those in the oligoarticular type group (P<0.05). The positive rates of AKA, ACPA, APF and RF-IgG in the systemic type group were lower than those in the polyarticular type group, with statistically significant differences (P<0.05); the positive rates of AKA, ACPA and APF in the polyarticular type group were higher than those in the oligoarticular type group, with statistically significant differences (P<0.05). 【Conclusion】 There are significant differences in the degree of immune dysfunction and the positive rate of arthritis antibodies in children with different subtypes of juvenile idiopathic arthritis, which may be related to their different pathogenesis.

Key words： Arthritis, Juvenile Immunoassay Antibodies

收稿日期: 2025-10-22

中图分类号:

R452

通讯作者: * E-mail:18261680601@163.com

引用本文:

王莹, 齐亚茹. 不同亚型幼年特发性关节炎患儿免疫功能指标及关节炎抗体比较[J]. 医学临床研究, 2026, 43(3): 439-441.
WANG Ying, QI Yaru. Comparison of Immunity and Arthritis Antibodies in Children with Different Subtypes of Juvenile Idiopathic Arthritis. JOURNAL OF CLINICAL RESEARCH, 2026, 43(3): 439-441.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.03.024 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I3/439

[1] SEN E S, RAMANAN A V. Juvenile idiopathic arthritis-associated uveitis[J].Best Pract Res Clin Rheumatol,2017,31(4):517-534.
[2] 周纬,胡坚. 生物标志物:从全身型幼年特发性关节炎诊疗分型到评价体系[J].中华实用儿科临床杂志, 2017,32(9):648-651.
[3] 朱光耀, 郝胜, 夏敏,等. 血清抵抗素水平在幼年特发性关节炎诊断中的意义[J].中华实用儿科临床杂志, 2020,35(14):1085-1088.
[4] 沈方方, 薛海燕, 曹兰芳. 血清淀粉样蛋白A在鉴别全身型幼年特发性关节炎患儿活动与感染中的意义[J].中华全科医师杂志, 2019, 18(1):61-65.
[5] ANGELES-HAN S T, RINGOLD S, BEUKELMAN T, et al. 2019 American college of rheumatology/arthritis foundation guideline for the screening, monitoring, and treatment of juvenile idiopathic arthritis-associated uveitis[J].Arthritis Care Res (Hoboken),2019,71(6):703-716.
[6] 曾华松.幼年特发性关节炎国际分类标准及治疗[J].实用儿科临床杂志, 2011,26(9):721-724.
[7] 潘伟, 孙杭. 血清炎性因子在全身型幼年特发性关节炎和川崎病患儿早期鉴别诊断中的价值[J].现代免疫学, 2019,32(5):393-396.
[8] 文旖旎,李红,刘凡. 幼年特发性关节炎医院感染患儿的临床特征及免疫指标分析[J].中华医院感染学杂志, 2019,29(15):2387-2391.
[9] RAMANAN A V, DICK A D, JONES A P, et al. Adalimumab plus methotrexate for uveitis in juvenile idiopathic arthritis[J].N Engl J Med,2017,27(17):1637-1646.
[10] 耿玲玲, 李丹, 冯媛,等. 幼年特发性关节炎细胞因子表达及其临床意义[J].中国妇幼健康研究, 2020,31(7):947-951.
[11] 冯淼,朱佳,何峰,等.辅助性T淋巴细胞22和白细胞介素-22在幼年特发性关节炎中的表达及与炎性因子水平的相关性[J].中华实用儿科临床杂志, 2020,35(15):1169-1172.
[12] MAHMUD S A, BINSTADT B A. Autoantibodies in the pathogenesis, diagnosis, and prognosis of juvenile idiopathic arthritis[J].Front Immunol,2019,14(9):3168-3169.
[13] 苏改秀, 黄小兰, 周志轩,等. 血清细胞因子水平监测在托珠单抗治疗幼年特发性关节炎全身型疗效评价中的应用[J].中华检验医学杂志, 2020, 43(1):85-90.
[14] 陶琳琳, 周娟, 唐雪梅,等. 不同亚型幼年特发性关节炎患者免疫功能特征[J].贵州医科大学学报, 2018, 43(4):78-82.
[15] 李胜男, 赖建铭, 黄小兰,等. 关节炎抗体在幼年特发性关节炎早期分型诊断及预后评估中的意义[J].中华检验医学杂志, 2019, 42(9):752-756.
[16] 薛海燕,陈伟,屠志强,等.Th17/Treg在幼年特发性关节炎合并特应质中的研究[J].临床儿科杂志,2019,37(10):731-735.
[17] MARTINI A, RAVELLI A, AVCIN T, et al. Toward new classification criteria for juvenile idiopathic arthritis: first steps, pediatric rheumatology international trials organization international consensus[J].J Rheumatol,2019,46(2):190-197.