Effects of Different Doses of Metoprolol Tartrate Combined with Basic Treatment on Cardiac Function and Heart Rate Variability in Elderly Patients with Conventional Hypertension and Heart Failure
SUN Yanpeng1, ZHU Yinchuan2
1. Guyang Town Health Center, Lankao Henan 475312; 2. the Second Affiliated Hospital of Zhengzhou University, Zhengzhou Henan 450000
Abstract：【Objective】 To investigate the effects of different doses of metoprolol tartrate combined with basic treatment on cardiac function and heart rate variability in elderly patients with hypertension and heart failure. 【Methods】 A retrospective analysis was conducted on the clinical data of 104 elderly patients with hypertension and heart failure admitted to two hospitals from June 2022 to February 2025. According to the different dosages of metoprolol tartrate administered, patients were divided into a low-dose group (conventional anti-heart failure basic treatment regimen + low-dose metoprolol tartrate) and a high-dose group (conventional anti-heart failure treatment regimen + high-dose metoprolol tartrate), with 52 cases in each group. The clinical efficacy, blood pressure [systolic blood pressure (SBP), diastolic blood pressure (DBP)], heart rate (HR), laboratory indicators [brain natriuretic peptide (BNP), high-sensitivity C-reactive protein (hs-CRP)], cardiac function indicators [left ventricular end-diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF), left ventricular end-systolic dimension (LVESD)], heart rate variability indicators [standard deviation of the average normal-to-normal intervals for all 5-minute segments over 24 hours (SDANN), root mean square of successive differences between adjacent normal-to-normal intervals (RMSSD), standard deviation of all normal-to-normal intervals over 24 hours (SDNN)], and adverse reactions were compared between the two groups. 【Results】 The total effective rate in the high-dose group was 92.31% (48/52), which was higher than 75.00% (39/52) in the low-dose group, and the difference was statistically significant (χ2=4.500, P<0.05). After treatment, HR, SBP, and DBP in both groups were lower than before treatment, and those in the high-dose group were lower than in the low-dose group, with statistically significant differences (P<0.05). Serum BNP and hs-CRP levels in both groups were lower than before treatment, and those in the high-dose group were lower than in the low-dose group, with statistically significant differences (P<0.05). LVESD and LVEDD in both groups were lower than before treatment, while LVEF was higher than before treatment; moreover, LVESD and LVEDD in the high-dose group were lower than in the low-dose group, and LVEF was higher than in the low-dose group, with statistically significant differences (P<0.05). SDANN, SDNN, and RMSSD in both groups were higher than before treatment, and those in the high-dose group were higher than in the low-dose group, with statistically significant differences (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the high-dose group and the low-dose group (P>0.05). 【Conclusion】 High-dose metoprolol tartrate can better improve cardiac function, heart rate, blood pressure, and heart rate variability indicators in elderly patients with hypertension and heart failure. Its efficacy is superior to that of low-dose, with good safety, and it is worthy of clinical promotion and application.
孙彦鹏, 朱银川. 不同剂量酒石酸美托洛尔联合常规基础治疗对老年高血压合并心力衰竭患者心功能、心率变异性指标的影响[J]. 医学临床研究, 2026, 43(2): 254-257.
SUN Yanpeng, ZHU Yinchuan. Effects of Different Doses of Metoprolol Tartrate Combined with Basic Treatment on Cardiac Function and Heart Rate Variability in Elderly Patients with Conventional Hypertension and Heart Failure. JOURNAL OF CLINICAL RESEARCH, 2026, 43(2): 254-257.
2026, Vol. 43 
