瘦素、胰高血糖素在结直肠癌组织中的表达水平及其意义<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2025.09.002

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摘要【目的】探讨瘦素(leptin, LEP)、胰高血糖素(glucagon, GCG)在结直肠癌(colorectal cancer, CRC)组织中的表达水平及其意义。【方法】收集2023年1月至2024年1月在本院接受手术治疗的34例CRC患者的CRC组织标本,检测LEP和GCG表达水平,分析其与CRC患者临床病理特征的相关性。【结果】34例CRC患者,年龄44～80(66.82±12.36)岁;男性占比58.82%(20/34);糖尿病患病率为52.94%(18/34);CRC患者体重指数(body mass index,BMI)为19.6～37.3(24.86±3.88)kg/m²,其中超重(23.5 kg/m²≤BMI<25.0 kg/m²)者占35.29%(12/34),肥胖(BMI≥25.0 kg/m²)者占11.76%(4/34)。免疫组化分析结果显示:LEP在CRC组织中的阳性表达与肿瘤直径(P=0.014)、分化等级(P=0.012)、TNM分期(P=0.014)及有无合并糖尿病(P=0.023)有关,LEP在CRC癌旁组织中的阳性表达与临床病理特征无相关性(P>0.05)。 GCG在CRC组织呈特征性缺失,其在Ⅰ/Ⅱ期和Ⅲ/Ⅳ期患者癌旁组织的表达存在显著差异(P<0.05)。【结论】CRC组织中LEP的表达和GCG在癌旁组织的表达与肿瘤进展及代谢特征显著相关,为代谢相关性CRC的靶向治疗提供了新方向。

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关键词 ：糖尿病, 结直肠肿瘤, 肥胖症, 瘦素, 胰高血糖素

Abstract：【Objective】 To investigate the expression levels of leptin(LEP) and glucagon(GCG) in colorectal cancer(CRC) tissues and their clinical significance.【Methods】 Tissue samples of CRC were collected from 34 patients who underwent surgical treatment in our hospital from January 2023 to January 2024. The expression levels of LEP and GCG were detected, and their correlations with the clinicopathological features of CRC patients were analyzed.【Results】 Among the 34 CRC patients, the age ranged from 44 to 80 years, with an average of(66.82±12.36) years; 58.82%(20/34) were male; the prevalence of diabetes was 52.94%(18/34); the body mass index(BMI) ranged from 19.6 to 37.3 kg/m², with an average of(24.86±3.88) kg/m². Among them, 35.29%(12/34) were overweight(23.5 kg/m²≤BMI<25.0 kg/m²) and 11.76%(4/34) were obese(BMI≥25.0 kg/m²). Immunohistochemical analysis showed that the positive expression of LEP in CRC tissues was correlated with tumor diameter(P=0.014), differentiation grade(P=0.012), TNM stage(P=0.014) and the presence of diabetes(P=0.023), while the positive expression of LEP in paracancerous tissues of CRC had no correlation with clinicopathological features(P>0.05). GCG showed characteristic deletion in CRC tissues, and there was a significant difference in the expression of GCG in paracancerous tissues between patients with stage Ⅰ/Ⅱ and stage Ⅲ/Ⅳ(P<0.05).【Conclusion】 The expression of LEP in CRC tissues and the expression of GCG in paracancerous tissues are significantly correlated with tumor progression and metabolic characteristics, which provides a new direction for the targeted therapy of metabolism-related CRC.

Key words： Diabetes Mellitus Colorectal Neoplasms Obesity Leptin Glucagon

收稿日期: 2025-06-13

中图分类号:

R735.35

基金资助:^*河南省重点研发与推广专项(科技攻关)项目(232102310193);河南省医学科技攻关计划联合共建项目(LHGJ20220941)

通讯作者: ^**E-mail:Yansl0908@163.com

引用本文:

冯晓晶, 闫顺笠, 孙慧敏, 李朝辉, 孙生安. 瘦素、胰高血糖素在结直肠癌组织中的表达水平及其意义^*[J]. 医学临床研究, 2025, 42(9): 1493-1497.
FENG Xiaojing, YAN Shunli, SUN Huimin, et al. Expression Levels and Significance of Leptin and Glucagon in Colorectal Cancer Tissues. JOURNAL OF CLINICAL RESEARCH, 2025, 42(9): 1493-1497.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.09.002 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I9/1493

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