Epidemiological Characteristics of 630 Patients with Novel Coronavirus Pneumonia in Shanghai to Analyze Related Factors Affecting the Time for Negative Nucleic Acid Negative Conversion
CHENG Si, ZHANG Jue, SUN Jian, et al
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203
Abstract：【Objective】To analyze the epidemiological characteristics and the influencing factors of the time of nucleic acid turning negative for patients infected with the new coronavirus pneumonia Omicron variant in Shanghai, and to provide reference for the treatment of patients with new coronary pneumonia. 【Methods】The epidemiological data of 630 new coronary pneumonia cases admitted to Shanghai Huangpu Fangcang Hospital from April to May, 2022 were retrospectively studied. According to the clinical classification criteria, patients were divided into asymptomatic/mild group (n=543) and common group (n=87). Based on the chest CT imaging diagnosis results, the patients were divided into group A (no obvious abnormality in chest CT plain scan, n=208), group B (chest imaging showed multiple small patchy shadows and interstitial changes, n=335), and group C (chest imaging showed multiple ground-glass shadows and infiltration shadows in multiple lungs, n=87). Statistical analysis was carried out based on chest imaging characteristics and nucleic acid detection results. 【Results】There were significant differences in gender, age, nucleic acid gene distribution ratio, N gene Ct value and ORF gene Ct value between the asymptomatic/mild group and the common group (P<0.05). There were significant differences in age, nucleic acid gene distribution ratio, N gene Ct value and ORF gene Ct value among group A, group B and group C (P<0.05). Logistic multivariate regression analysis showed that age, N gene Ct value and ORF gene Ct value were influencing factors for the severity of pneumonia in patients (P<0.05). According to the time of nucleic acid negative conversion, patients were divided into group D (nucleic acid negative conversion time <9 d, n=5) and group E (nucleic acid negative conversion time ≥9 d, n=12). There were significant differences in age, N gene Ct value and ORF gene Ct value of patients in group D and group E (P<0.05). Logistic multivariate regression analysis showed that age, N gene Ct value and ORF gene Ct value at admission were not independent risk factors affecting the time for nucleic acid test to turn negative (all P>0.05).【Conclusion】Epidemiological characteristics of patients with new coronary pneumonia:gender, age and nucleic acid Ct value are meaningful for the clinical classification of new coronary pneumonia, but have no significant effect on the time of viral nucleic acid conversion to negative; The degree of inflammatory changes in the lungs of patients with new coronary pneumonia is related to age and viral nucleic acid content.
成思, 张珏, 孙健, 石磊. 上海市630例新型冠状病毒Omicron变异株感染者流行病学特征及影响核酸转阴时间的相关因素*[J]. 医学临床研究, 2024, 41(9): 1281-1284.
CHENG Si, ZHANG Jue, SUN Jian, et al. Epidemiological Characteristics of 630 Patients with Novel Coronavirus Pneumonia in Shanghai to Analyze Related Factors Affecting the Time for Negative Nucleic Acid Negative Conversion. JOURNAL OF CLINICAL RESEARCH, 2024, 41(9): 1281-1284.
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2024, Vol. 41 
