Abstract:【Objective】To analyze the specific situation of newly diagnosed occupational disease cases in Hunan Province in recent years in order to make recommendations for the focus of occupational disease prevention and control.【Methods】Obtain newly diagnosed and reported occupational disease report data of Hunan Province from 2016 to 2018 from the National Occupational Disease and Occupational Health Information Monitoring System. Statistical analysis software SPSS21 was used to analyze the distribution of different occupational disease types, different economic types, enterprise sizes, and occupational disease occurrence in the administrative city.【Results】A total of 6785 cases of various occupational diseases were newly diagnosed in Hunan Province from 2016 to 2018, of which 5490 cases were pneumoconiosis (80.91%). The new occupational diseases from 2016 to 2018 were mainly coal workers pneumoconiosis (4014 cases, 59.16%), followed by 1392 silicosis cases (20.52 %) and arsenic and its compound poisoning (1029 cases, 15.17%). Using the Kruskal-walis test, the results show that there were differences in terms of the working age for coal workers' pneumoconiosis, silicosis and other pneumoconiosis patients. The median working age of silicosis is less than that of coal workers' pneumoconiosis and other types of pneumoconiosis (P<0.01). There are 5045 cases of state-owned The new cases of occupational diseases from 2016 to 2018 were mainly state-owned enterprises (5045 cases, 74.35%), followed by private enterprises (1549 cases, 22.83%) and other enterprises (191 cases, 2.82%). From the perspective of enterprise scale, 382 cases (5.63%) were from large enterprises, 2475 cases (36.48%) from medium-sized enterprises, 3634 cases (53.56%) from small enterprises, 35 cases of micro-enterprises (0.52%) and 259 cases with unknown scale enterprises (3.82%). From the perspective of administrative city, Loudi had the largest number (1777 cases, 26.20%), followed by Changde (889 cases,13.10%) and Yueyang (776 cases,11.44%).【Conclusion】From 2016 to 2018 in Hunan Province, newly diagnosed occupational diseases are mainly caused by coal workers' pneumoconiosis, silicosis, arsenic and arsenic compounds poisoning. All cases come from state-owned enterprises. The main patients are workers from small medium enterprises. Loudi, Changde and Yueyang have more newly diagnosed and reported cases. Relevant departments should not only encourage enterprises to actively carry out occupational health protection and occupational health inspections, and provide conditions for the diagnosis of occupational diseases for sick employees, but also urge and supervise enterprises to do a good job of protecting occupational hazards.