阿替普酶静脉溶栓治疗对急性脑梗死患者血清sCD163、ANGPTL3水平的影响

doi:10.3969/j.issn.1671-7171.2026.09.019

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Abstract 【Objective】To investigate the effects of intravenous thrombolysis with alteplase on serum soluble CD163 (sCD163) and angiopoietin-like protein 3 (ANGPTL3) levels in patients with acute cerebral infarction (ACI). 【Methods】Eighty patients with ACI admitted to our hospital between August 2021 and August 2024 were enrolled as the observation group, while 80 healthy individuals undergoing physical examinations during the same period were selected as the control group. According to the National Institutes of Health Stroke Scale (NIHSS) score at admission, patients in the observation group were classified into the mild group (n=35) and severe group (n=45). Based on the modified Rankin Scale score at 3 months after thrombolysis, patients were further divided into the favorable-prognosis group (n=56) and poor-prognosis group (n=24). Serum sCD163 and ANGPTL3 concentrations were measured. Spearman correlation analysis was performed to evaluate the associations of these biomarkers with the severity of neurological impairment. Receiver operating characteristic (ROC) curves were constructed to assess the predictive value for prognosis after thrombolysis. 【Results】 Before thrombolysis, serum sCD163 and ANGPTL3 levels were higher in the observation group than in the control group; and the levels of serum sCD163 and ANGPTL3 in the severe group were higher than those in the mild group (P<0.05). Both serum sCD163 and ANGPTL3 biomarkers were positively correlated with the severity of neurological impairment (P<0.05). Levels of sCD163 and ANGPTL3, both before and after thrombolysis, were higher in the poor-prognosis group than in the favorable-prognosis group (P<0.05). ROC analysis showed that the combined assessment of sCD163 and ANGPTL3 yielded an area under the curve of 0.952 for predicting prognosis after thrombolysis, with a sensitivity of 95.8% and a specificity of 98.2%, outperforming either marker alone (P<0.05). 【Conclusion】 Serum sCD163 and ANGPTL3 levels are elevated in patients with ACI and they are associated with the severity of neurological impairment and clinical prognosis.

Key words： Acute Cerebral Infarction Alteplase Intravenous Thrombolysis Soluble CD163 Angiopoietin-Like Protein 3

Received: 09 May 2025

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R743.33

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	WANG Yachan
	CHEN Yufei
	WANG Qiuju

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WANG Yachan,CHEN Yufei,WANG Qiuju. Effects of Intravenous Thrombolysis with Alteplase on Serum sCD163 and ANGPTL3 Levels in Patients with Acute Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(9): 1478-1480.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.09.019 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I9/1478

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