妊娠期高血压孕妇胎膜组织中自噬相关蛋白的表达与不良妊娠结局的相关性

doi:10.3969/j.issn.1671-7171.2026.08.014

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Abstract 【Objective】 To explore the correlation between the expression of autophagy-related proteins in fetal membrane tissues and adverse pregnancy outcomes in pregnant women with gestational hypertension. 【Methods】 A total of 86 pregnant women with gestational hypertension who received regular prenatal examinations in Dancheng County Maternal and Child Health Hospital from May 2020 to May 2023 were enrolled as the observation group and further divided into good-outcome subgroup and adverse-outcome subgroup according to pregnancy outcomes. Another 86 normal pregnant women receiving regular prenatal examinations during the same period were selected as the control group. Clinical data of all subjects were collected. Immunohistochemical staining was used to detect the expression of autophagy-related proteins Beclin-1, microtubule-associated protein 1 light chain 3-Ⅱ (LC3-Ⅱ) and sequestosome-1 (p62) in fetal membrane tissues. Risk factors for adverse pregnancy outcomes in patients with gestational hypertension were screened, and the predictive value of Beclin-1, LC3-Ⅱ and p62 expression in fetal membranes for adverse pregnancy outcomes was analyzed. 【Results】 The expression levels of Beclin-1 and LC3-Ⅱ in fetal membrane tissues of the observation group were higher than those of the control group (all P<0.05), while p62 level was lower (P<0.05). Among the 86 patients with gestational hypertension, 32 cases developed adverse pregnancy outcomes. The 24-hour urinary protein quantification, serum uric acid, vascular endothelial growth factor (VEGF), Beclin-1, LC3-Ⅱ, and the proportions of CD3⁺, CD56⁺, CD68⁺ positive cells in the adverse-outcome subgroup were higher than those in the good-outcome subgroup (all P<0.05), whereas p62 level was lower (P<0.05). 24-hour urinary protein quantification, serum uric acid, VEGF, Beclin-1, LC3-Ⅱ, p62, CD3⁺, CD56⁺ and CD68⁺ were influencing factors for adverse pregnancy outcomes in gestational hypertension (P<0.05). The area under the curve values of Beclin-1, LC3-Ⅱ, p62 and their combination for evaluating adverse pregnancy outcomes were 0.803, 0.792, 0.821 and 0.889, respectively. 【Conclusion】 Abnormal expression of Beclin-1, LC3-Ⅱ and p62 in fetal membrane tissues is correlated with adverse pregnancy outcomes in patients with gestational hypertension, which can assist in assessing the risk of adverse pregnancy outcomes.

Key words： Hypertension, Pregnancy-Induced Extraembryonic Membranes Autophagy Pregnancy Outcome

Received: 01 July 2025

PACS:

R714.252

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	XIA Wenxiang
	ZHENG Beibei
	LIU Na

Cite this article:

XIA Wenxiang,ZHENG Beibei,LIU Na. Correlation between the Expression of Autophagy-Related Proteins in Fetal Membrane Tissues and Adverse Pregnancy Outcomes in Pregnant Women with Gestational Hypertension[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(8): 1283-1286.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.08.014 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I8/1283

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