阿托伐他汀联合机械血栓抽吸术治疗急性大血管闭塞性缺血性脑卒中患者的效果

doi:10.3969/j.issn.1671-7171.2026.08.007

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Abstract 【Objective】 To investigate the efficacy of atorvastatin combined with mechanical thrombectomy in patients with acute ischemic stroke with large-vessel occlusion (AIS-LVO). 【Methods】 The clinical data of 102 patients with AIS-LVO admitted to Luoyang Xinlicheng Hospital from January 2022 to December 2024 were retrospectively analyzed. Patients were divided into the control group (mechanical thrombectomy) and the observation group (atorvastatin combined with mechanical thrombectomy) according to treatment regimens, with 51 cases in each group. Clinical efficacy, incidence of vascular restenosis, blood lipid indicators [total cholesterol (TC), triglyceride (TG)], inflammatory factors [interleukin-8 (IL-8), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor α (TNF-α)], neurological function [modified Rankin Scale (mRS) score], prognosis and incidence of adverse reactions were compared between the two groups. 【Results】 The total effective rate of the observation group was higher than that of the control group (P<0.05). The incidence of vascular restenosis in the observation group was lower than that in the control group (P<0.05). After treatment, serum levels of TC, TG, IL-8, hs-CRP and TNF-α decreased in both groups, and were lower in the observation group (all P<0.05). At 8-week follow-up after treatment, the observation group obtained lower mRS score and better prognosis compared with the control group (all P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Atorvastatin combined with mechanical thrombectomy yields favorable efficacy for AIS-LVO. It can reduce the incidence of vascular restenosis, improve blood lipid profiles, decrease inflammatory factor levels, ameliorate neurological function and prognosis, with satisfactory safety.

Key words： Brain Ischemia Arterial Occlusive Diseases Atorvastatin Thrombectomy Restenosis

Received: 23 October 2025

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R743.31

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	ZHOU Fugao

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ZHOU Fugao. Efficacy of Atorvastatin Combined with Mechanical Thrombectomy in Patients with Acute Ischemic Stroke with Large Vessel Occlusion[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(8): 1256-1259.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.08.007 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I8/1256

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