颈动脉超声指标及血浆miR-146a、miR-214相对表达量与高脂血症患者发生冠心病的相关性

doi:10.3969/j.issn.1671-7171.2026.07.026

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Abstract 【Objective】 To explore the correlation between carotid ultrasound parameters, relative expression levels of plasma miR-146a, miR-214 and coronary heart disease (CHD) in patients with hyperlipidemia. 【Methods】 A total of 90 hyperlipidemic patients with suspected high risk of CHD admitted to the two hospitals from July 2022 to July 2024 were enrolled. According to coronary angiography results, patients were divided into observation group (complicated with CHD, n=68) and control group (without CHD, n=22). General data, laboratory indicators including triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), miR-146 and miR-214, as well as carotid ultrasound parameters including intima-media thickness (IMT), and carotid Crouse plaque score ambulatory arterial stiffness index (AASI) were compared between the two groups. Influencing factors for CHD in hyperlipidemic patients were analyzed, and a prediction model based on carotid ultrasound indicators and plasma miR-146a, miR-214 expression was constructed and verified. 【Results】 There was no significant difference in TG and HDL-C levels between the two groups (P>0.05). TC, IMT, AASI, carotid Crouse plaque score, miR-146a and miR-214 in the observation group were significantly higher than those in the control group (P<0.05). Logistic regression analysis showed that TC (OR=4.483), IMT(OR=19.739), AASI (OR=2.854), carotid Crouse plaque score (OR=4.999), miR-146a (OR=12.849) and miR-214 (OR=3.438) were risk factors for CHD in hyperlipidemic patients (P<0.05). ROC curve analysis demonstrated that the combined model had a sensitivity of 0.868, specificity of 0.955 and AUC of 0.964 for predicting CHD. 【Conclusions】 Carotid ultrasound parameters and relative expression of plasma miR-146a, miR-214 are correlated with the occurrence of CHD in hyperlipidemic patients. The established comprehensive prediction model has favorable predictive efficiency and can assist in evaluating the risk of CHD.

Key words： Hyperlipidemias Coronary Disease Carotid Arteries Ultrasonography MicroRNAs

Received: 08 January 2026

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R589.21

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	MA Liping
	CHEN Jing
	ZHAO Wei

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MA Liping,CHEN Jing,ZHAO Wei. Correlation between Carotid Ultrasound Parameters, Relative Expression of Plasma miR-146a and miR-214 and Coronary Heart Disease in Patients with Hyperlipidemia[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(7): 1148-1151.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.07.026 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I7/1148

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