不同他汀类药物联合双联抗血小板对急性ST段抬高型心肌梗死PCI术后患者脂质代谢指标及心功能的影响

doi:10.3969/j.issn.1671-7171.2026.05.019

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Abstract 【Objective】 To compare the effects of different statins combined with dual antiplatelet therapy on lipid metabolism indexes and cardiac function in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention (PCI). 【Methods】 A total of 80 patients with acute ST-segment elevation myocardial infarction who underwent PCI in our hospital from April 2020 to August 2024 were enrolled and divided into the control group (n=37) and the observation group (n=43) by random number table method. The control group received atorvastatin combined with dual antiplatelet therapy, while the observation group received rosuvastatin combined with dual antiplatelet therapy. The two groups were compared in cardiac function indicators [Left Ventricular Ejection Fraction (LVEF), Left Ventricular End-Systolic Diameter (LVESD), Left Ventricular End-Diastolic Diameter (LVEDD)] and laboratory indexes [cardiac troponin I (cTnI), creatine kinase isoenzyme (CK-MB), N-terminal pro-brain natriuretic peptide (NT-proBNP), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (ApoA1), apolipoprotein E (ApoE), triglyceride (TG), apolipoprotein B (ApoB), low-density lipoprotein cholesterol (LDL-C), and platelet aggregation rate (PAR)]. The incidence of major adverse cardiovascular events (MACE) and adverse reactions within half a year after PCI were recorded in both groups. 【Results】 After treatment, LVEF increased, LVESD and LVEDD decreased in both groups; the observation group had higher LVEF and lower LVESD, LVEDD than the control group (P<0.05). After treatment, the levels of cTnI, CK-MB, NT-proBNP and PAR in both groups were lower than those before treatment; cTnI, NT-proBNP and PAR in the observation group were lower than those in the control group (P<0.05). After treatment, HDL-C and ApoA1 increased, while TG, LDL-C, ApoE and ApoB decreased in both groups; the observation group had higher HDL-C, ApoA1 and lower TG, LDL-C, ApoE, ApoB than the control group (P<0.05). There were no significant differences in the incidence of MACE and total adverse reaction rate within half a year after PCI between the two groups (P>0.05). 【Conclusion】 Rosuvastatin combined with dual antiplatelet therapy is superior to atorvastatin combined with dual antiplatelet therapy in repairing damaged myocardium, improving cardiac function and regulating lipid metabolism disorder in patients with acute ST-segment elevation myocardial infarction after PCI.

Key words： ST Elevation Myocardial Infarction Acute Disease Hydroxymethylglutaryl-CoA Reductase Inhibitors Platelet Aggregation Inhibitors Percutaneous Coronary Intervention

Received: 14 August 2025

PACS:

R542.22

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	SHANG Yuanyuan
	LUY Xiaohui

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SHANG Yuanyuan,LUY Xiaohui. Effects of Different Statins Combined with Dual Antiplatelet Therapy on Lipid Metabolism Indexes and Cardiac Function in Patients with Acute ST-Segment Elevation Myocardial Infarction after PCI[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(5): 773-776.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.05.019 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I5/773

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