氯化钾片相关性胃黏膜损伤的影响因素分析

doi:10.3969/j.issn.1671-7171.2025.11.015

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Abstract 【Objective】To explore the influencing factors for potassium chloride tablet-associated gastric mucosal injury. 【Methods】A total of 88 patients who received potassium chloride tablet treatment in our hospital from April 2022 to November 2023 were selected. The Modified Lanza Scale (MLS) for gastric mucosal injury was used to assess whether gastric mucosal injury occurred. According to the presence of gastric mucosal injury, the patients were divided into the occurrence group (n=34, MLS score 1–5) and the non-occurrence group (n=54, MLS score 0). Gender, age, body mass index (BMI), smoking, alcohol consumption, history of peptic ulcer, history of cardiovascular and cerebrovascular diseases, Helicobacter pylori (Hp) infection, levels of prostaglandin E₂ (PGE₂) and monocyte chemoattractant protein-1 (MCP-1), activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) were compared between the two groups. Multivariate Logistic regression analysis was used to identify the risk factors for potassium chloride tablet-associated gastric mucosal injury, and receiver operating characteristic (ROC) curve was used to analyze the efficacy of each index in predicting this injury. 【Results】There were no statistically significant differences between the two groups in gender, age, BMI, smoking history, alcohol consumption history, history of peptic ulcer, history of cardiovascular and cerebrovascular diseases, or serum levels of PGE₂ and MCP-1 (P>0.05); significant differences were found in the proportion of Hp infection, APTT, PT, and TT between the two groups (P<0.05). Multivariate Logistic regression analysis showed that Hp infection and prolonged APTT, PT, and TT were independent risk factors for potassium chloride tablet-associated gastric mucosal injury (P<0.05). Spearman correlation analysis revealed that ulcer diameter, area of thick coating at the ulcer base, area of surrounding mucosal congestion, and number of ulcers were positively correlated with MLS score (r_s=0.477, 0.435, 0.492, 0.399; mean P<0.05). The sensitivity (85.29%), specificity (83.33%), accuracy (82.95%), and Kappa value (0.664) of the combined prediction using Hp infection status, APTT, PT, and TT for potassium chloride tablet-associated gastric mucosal injury were higher than those of single indexes (P<0.05).【Conclusion】Clinicians can comprehensively assess the risk of potassium chloride tablet-associated gastric mucosal injury in patients based on Hp infection status and coagulation function indexes. This helps to more accurately identify high-risk patients and take preventive measures in advance.

Key words： Stomach Diseases Gastric Mucosa Potassium Chloride Root Cause Analysis

Received: 25 June 2024

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	WANG Yanyan
	LI Yingxiao
	ZHU Zhenzhen

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WANG Yanyan,LI Yingxiao,ZHU Zhenzhen. Analysis of Influencing Factors for Potassium Chloride Tablet-Associated Gastric Mucosal Injury[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(11): 1895-1898.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.11.015 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I11/1895

[1] 周民. 高龄消化性溃疡患者复发与用药类型和种类的相关性研究[J].国际医药卫生导报,2018,24(5):655-658.
[2] PELLEGRINO C, MICHELE R, CHIARA M, et al. From Sidney to OLGA: an overview of atrophic gastritis[J].Acta Biomed,2018, 89(8-s):93-99.
[3] 王涵,杨敏一,曾行,等.胃黏膜损伤修复模型研究进展[J].中国药师,2022,25(8):1431-1435.
[4] 张凯军,朱文舜,卢晓乐,等. 老年脓毒症患者胃镜下改良Lanza评分与预后的关系[J]. 中华消化内镜杂志,2023,40(11):909-914.
[5] TARNAWSKI A S, AHLUWALIA A. Increased susceptibility of aging gastric mucosa to injury and delayed healing: clinical implications[J].World J Gastroenterol,2018, 24(42): 4721.
[6] KIM H K, KIM J I, KIM J K, et al. Preventive effects of rebamipide on NSAID-induced gastric mucosal injury and reduction of gastric mucosal blood flow in healthy volunteers[J].Dig Dis Sci, 2007, 52: 1776-1782.
[7] 郭福勇. 小剂量阿司匹林致胃损伤的临床观察[J].现代中西医结合杂志,2010,19(19):2408.
[8] 赵辽辽,陈晶,杜雅菊. 阿司匹林及氯比格雷相关胃损伤治疗新进展[J].胃肠病学和肝病学杂志,2016,25(4):461-464.
[9] 刘淑洁,李敏,马婧怡,等. 氯化钾缓释片人体生物等效性研究需关注的一些问题[J].中国新药杂志,2020,29(15):1707-1710.
[10] Du J, Li X H, Liu F, et al. Role of the outer inflammatory protein a/cystine–glutamate transporter pathway in gastric mucosal injury induced by Helicobacter pylori[J].Clin Transl Gastroenterol,2020, 11(5): e00178.
[11] MALFERTHEINER P, SELGRAD M. Helicobacter pylori infection and current clinical areas of contention[J].Curr Opin Gastroenterol,2010, 26(6): 618-623.
[12] ADINORTEY M B, ANSAH C, ADINORTEY C A, et al. Isolation of Helicobacter pylori from gastric biopsy of dyspeptic patients in Ghana and in vitro preliminary assessment of the effect of Dissotis rotundifolia extract on its growth[J].J Trop Med,2018, 2018: 8071081.
[13] SAGHIER S, SCHWARZ S M, ANDERSON V, et al. Pediatric Helicobacter pylori gastropathy demonstrates a unique pattern of gastric foveolar hyperplasia[J].Helicobacter,2018,23(3): e12487.