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| Correlation between Serum cys C and BNP Levels and Cardiac Function and Prognosis in Elderly Hypertensive Patients |
| LI Yaru, GUO Wanwan, YANG Yan |
| Department of Cardiology, Nanyang First People's Hospital, Nanyang Henan 473000 |
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Abstract 【Objective】To explore the correlation between serum cystatin C (cys C) and brain natriuretic peptide (BNP) levels and cardiac function and prognosis in elderly hypertensive patients. 【Methods】A total of 120 elderly hypertensive patients admitted to our hospital from September 2020 to June 2023 were selected. All patients were followed up for 3 years and divided into a good prognosis group (n=74) and a poor prognosis group (n=46) according to whether major adverse cardiovascular events occurred during follow-up. Meanwhile, 57 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. Serum cys C and BNP levels, as well as cardiac function indexes [left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), 6-minute walk distance (6MWD)] were compared among the three groups. Pearson correlation coefficient was used to evaluate the correlation between serum cys C and BNP levels and prognosis; Spearman correlation analysis was used to analyze the correlation between serum cys C and BNP levels and cardiac function. 【Results】The serum cys C and BNP levels in the poor prognosis group were higher than those in the control group and the good prognosis group, with statistically significant differences (P<0.05). LVEDD and LVESD in the poor prognosis group were significantly higher than those in the control group and the good prognosis group, while LVEF and 6MWD were significantly lower than those in the control group and the good prognosis group, with statistically significant differences (mean P<0.05). Pearson correlation analysis showed that serum cys C and BNP levels were positively correlated with poor prognosis (r=0.464, 0.989; all P<0.05). Spearman correlation analysis showed that serum cys C and BNP levels were significantly correlated with cardiac function indexes (LVEDD, LVESD, LVEF, 6MWD) in elderly hypertensive patients (all P<0.05). 【Conclusion】Serum cys C and BNP levels are abnormally elevated in elderly hypertensive patients, and they can be used as important indicators to evaluate cardiac function and prognosis in elderly hypertensive patients.
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Received: 22 July 2025
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[1] 左颖婷,吴寿岭,陈朔华,等. 糖代谢异常人群中不同高血压亚型的心脑血管疾病风险[J].首都医科大学学报,2023,44(1):42-48.
[2] 杜荣,高晶蓉,江佳艳,等. 社区老年高血压患者健康自我管理能力及服药依从性的相关性分析[J].中国健康教育,2023,39(4):310-314.
[3] 于运,张铭,王俊. 血清胱抑素C、尿液肾损伤分子-1评估妊娠期高血压疾病患者肾小管间质损伤程度的意义[J].中国妇幼健康研究,2023,34(2):34-39.
[4] 夏方肖,郝文科,梁锦秀,等. 血清胱抑素C与血肌酐在评价老年住院患者肾功能损伤中的比较分析[J].国际泌尿系统杂志,2023,43(3):407-411.
[5] 谢祖刚,谢根萍,陈龙庚,等. 袢利尿剂对终末期肾病无尿患者容量控制的疗效观察[J].国际泌尿系统杂志,2020,40(3):411-415.
[6] 曹蓓迪,李波漩,孟智宏. 针刺治疗高血压病时效关系述评[J].中国中医基础医学杂志,2023,29(6):987-990.
[7] 宋超强,赵保钢,孙智宏. 不同微创颅内血肿清除术对老年高血压性脑出血患者神经功能恢复的影响[J].中华老年心脑血管病杂志,2023,25(7):725-728.
[8] 程晓冉,张笑天,李明月,等. 医防融合背景下慢性病随访对高血压和糖尿病患者健康行为及血压/血糖控制的影响研究[J].中国全科医学,2023,26(28):3482-3488.
[9] 吕新才,卢家忠. 血清胱抑素C、脑钠肽及白细胞介素-33在急性心肌梗死患者中的表达水平及预后价值[J].中国临床药理学杂志,2022,38(18):2124-2127.
[10] 付琳,王敏,李瑾. 冠心病病人载脂蛋白B/载脂蛋白A1、胱抑素C、血清胆红素水平变化及其与冠状动脉病变严重程度的相关性[J].中西医结合心脑血管病杂志,2022,20(7):1287-1292.
[11] 闫杰,赵红,刘艳军,等. 重组人脑型钠尿肽对急性射血分数降低心衰患者血清ACE2水平的影响[J].天津医药,2017,45(4):372-376.
[12] 康路,忽德运,王攀. 冠心病患者经胸超声心动图定量参数和心室重塑相关血清指标关系及对预后预测价值[J].临床误诊误治,2023,36(4):57-62.
[13] 郭咏娣,武剑,宋晓微. DWI联合BNP、CysC及LDH检测在急性脑梗死预后判断中的作用[J].分子诊断与治疗杂志,2023,15(7):1164-1168.
[14] 刘杰杰,舒亮辉,蒋薇,等. 血清胱抑素C、超敏C反应蛋白预测老年心律失常心力衰竭病人预后的效能研究[J].实用老年医学,2022,36(3):273-276.
[15] 王晓亮,郑伟,赵娜,等. 血清HE4、Cystatin C及BNP与慢性心力衰竭病人心力衰竭严重程度及预后的相关性分析[J].蚌埠医学院学报,2022,47(10):1416-1420. |
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2025, Vol. 42 
