Scr、cys C、BUN对重症急性胰腺炎并发急性肾损伤的预测效能

doi:10.3969/j.issn.1671-7171.2025.08.017

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Abstract 【Objective】To evaluate the predictive value of serum creatinine (Scr), cystatin C (cys C), and blood urea nitrogen (BUN) for acute kidney injury (AKI) in patients with severe acute pancreatitis (SAP).【Methods】 A total of 89 patients with SAP were enrolled and divided into two groups based on the occurrence of AKI: the AKI group (33 cases) and the non-AKI group (56 cases). Clinical data, Scr, cys C, and BUN levels were compared between the two groups. Univariate and multivariate logistic regression analyses were performed to identify risk factors for SAP complicated by AKI. Receiver operating characteristic (ROC) curves were used to analyze the predictive efficiency of Scr, cys C, and BUN.【Results】 Levels of Scr, cys C, and BUN were significantly higher in the AKI group compared to the non-AKI group (P<0.05). Univariate analysis showed that APACHE Ⅱ score, blood lactate, Ranson score, abdominal compartment syndrome (ACS), systemic inflammatory response syndrome (SIRS), shock, mechanical ventilation, C-reactive protein, procalcitonin, and serum calcium were associated with AKI occurrence (P<0.05). Multivariate logistic regression revealed that high APACHE Ⅱ score, high Ranson score, low serum calcium, elevated Scr, cys C, and BUN were independent risk factors for AKI in SAP patients (P<0.05). ROC curve analysis demonstrated that the combination of APACHE Ⅱ score, Ranson score, serum calcium, Scr, cys C, and BUN had a higher predictive value than any single indicator.【Conclusion】 Scr, cys C, and BUN levels are elevated in SAP patients with AKI. When the levels of Scr, cys C, and BUN combined with APACHE Ⅱ score, Ranson score, and serum calcium, they offer an even better predictive value for early identification of AKI in SAP.

Key words： Pancreatitis, Acute Necrotizing Acute Kidney Injury Blood Urea Nitrogen Chalones

Received: 17 October 2024

PACS:

R657.51

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	YANG Yuchen
	FANG Wei

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YANG Yuchen,FANG Wei. Predictive Value of Scr, cys C, and BUN for Acute Kidney Injury in Severe Acute Pancreatitis[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(8): 1353-1356.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.08.017 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I8/1353

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