IL-6/STAT3信号通路相关因子对下肢动脉硬化闭塞症介入治疗后再狭窄的预测价值杨帆

doi:10.3969/j.issn.1671-7171.2025.08.013

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Abstract 【Objective】To investigate the predictive value of interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway-related factors for restenosis after endovascular therapy in patients with lower extremity arteriosclerosis obliterans (LEASO). 【Methods】A total of 125 LEASO patients admitted to our hospital between January 2020 and January 2023 were enrolled. Patients were divided into poor-prognosis group (vascular restenosis >50%, n=41) and good-prognosis group (n=84) based on follow-up outcomes. Serum levels of IL-6, IL-6 receptor (IL-6R), Janus kinase 2 (JAK2), STAT3, vascular endothelial growth factor (VEGF), and nitric oxide (NO) were measured. Logistic regression analysis was used to identify risk factors for restenosis. Receiver operating characteristic (ROC) curves evaluated the predictive efficiency of the IL-6/STAT3 pathway. 【Results】 Poor-prognosis patients showed higher total cholesterol (TC) levels and lower ankle-brachial index (ABI) compared to good-prognosis patients (all P<0.05). Serum IL-6, IL-6R, JAK2, STAT3, and VEGF levels were significantly elevated, while NO levels were decreased in the poor-prognosis group (mean P<0.05). Multivariate analysis revealed high IL-6, IL-6R, JAK2, STAT3, VEGF levels and low NO levels as independent risk factors for restenosis (P<0.05). The ROC curve showed that the combined detection of IL-6, IL-6R, JAK2, and STAT3 had high diagnostic efficacy for the prognosis of patients with lower extremity arteriosclerosis obliterans who underwent interventional therapy.【Conclusion】IL-6/STAT3 pathway-related factors are closely associated with restenosis risk after endovascular therapy in LEASO patients. Elevated IL-6, IL-6R, JAK2, and STAT3 levels indicate higher restenosis probability.

Key words： Interleukin-6 STAT3 Transcription Factor Arteriosclerosis Obliterans Lower Extremity Endovascular Procedures Constriction, Pathologic

Received: 19 February 2025

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	YANG Fan
	ZHANG Yu
	ZANG Sheng

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YANG Fan,ZHANG Yu,ZANG Sheng. Predictive Value of IL-6/STAT3 Signaling Pathway-Related Factors for Restenosis after Endovascular Therapy in Lower Extremity Arteriosclerosis Obliterans[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(8): 1339-1342.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.08.013 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I8/1339

[1] CUI L Y, CHEN L T, DAI Y X, et al. Increased level of Tim-3⁺PD-1⁺CD4⁺T cells with altered function might be associated with lower extremity arteriosclerosis obliterans[J].Front Immunol,2022, 13:871362.
[2] 张克,杨涛,郝斌. 下肢动脉硬化闭塞症患者支架植入术后血清miR-140-5p与1年内支架内再狭窄相关性研究[J].介入放射学杂志,2022,31(6):555-559.
[3] ZHAO X K, ZHU M M, WANG S N, et al. Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and Ecs[J].Acta Pharmacol Sin,2023, 44(8):1625-1636.
[4] RAPP J, JUNG M, KLAR R F U,et al. STAT3 signaling induced by the IL-6 family of cytokines modulates angiogenesis[J].J Cell Sci,2023, 136(1):jcs260182.
[5] 中华医学会外科学分会血管外科学组. 下肢动脉硬化闭塞症诊治指南[J].中华医学杂志,2015,95(24):1883-1896.
[6] STONE K, FRYER S, FAULKNER J,et al. Associations of lower-limb atherosclerosis and arteriosclerosis with cardiovascular risk factors and disease in older adults: the Atherosclerosis Risk in Communities (ARIC) study[J].Atherosclerosis,2022, 340:53-60.
[7] 逯莹,甘红艳,袁艳艳,等. 下肢动脉硬化闭塞症介入术后患者运动康复依从性影响因素研究现状[J].介入放射学杂志,2023,32(3):288-292.
[8] SHI P X, JI H L, ZHANG H J, et al. circANRIL reduces vascular endothelial injury, oxidative stress and inflammation in rats with coronary atherosclerosis[J].Exp Ther Med,2020, 20(3):2245-2251.
[9] PEI C Z, SEOK J, KIM G J, et al. Deficiency of HtrA4 in BeWo cells downregulates angiogenesis through IL-6/JAK/STAT3 signaling[J].Biomed Pharmacother,2023, 166:115288.
[10] PAPASTAMOS C, ANTONOPOULOS A S, SIMANTIRIS S, et al. Interleukin-6 signaling in atherosclerosis: from molecular mechanisms to clinical outcomes[J].Curr Top Med Chem,2023, 23(22):2172-2183.
[11] MARKIN A M, MARKINA Y V, BOGATYREVA A I, et al. The role of cytokines in cholesterol accumulation in cells and atherosclerosis progression[J].Int J Mol Sci,2023, 24(7):6426.
[12] KIM K D, KIM H, CHO S, et al. Ultrasound elastography to differentiate the thrombus and plaque in peripheral arterial diseases[J].Vasc Specialist Int,2022, 38:34.
[13] 周丽,韩亚庆,崔玉玲,等. 踝肱指数评估下肢动脉硬化闭塞肢体缺血严重程度的CT血管成像影响因素分析[J].实用放射学杂志,2023,39(6):924-927.
[14] LI S J, CHANG H M, WANG J H, et al. The interleukin-6 trans-signaling promotes progesterone production in human granulosa-lutein cells[J].Biol Reprod,2022, 106(5):953-967.
[15] LOPES E, MACHADO-OLIVEIRA G, SIMÕES C G, et al.Cholesteryl hemiazelate present in cardiovascular disease patients causes lysosome dysfunction in murine fibroblasts[J].Cells,2023, 12(24):2826.
[16] LIU Y L, CUI Y Z, ZHOU Z Q, et al. Relationship between angiotensin Ⅱ, vascular endothelial growth factor, and arteriosclerosis obliterans[J].Dis Markers,2023, 2023:1316821.
[17] O'BRIEN B J, SINGER H A, ADAM A P, et al. CaMKIIδ is upregulated by pro-inflammatory cytokine IL-6 in a JAK/STAT3-dependent manner to promote angiogenesis[J].FASEB J,2021, 35(4):e21437.