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| Effect of Ticagrelor or Clopidogrel on Circulating MicroRNA Levels after Stent Implantation in Patients with Acute Myocardial Infarction |
| LI Hui, ZHANG Youjian, LIU Danyang |
| Xihua County People's Hospital,Zhoukou Henan 466600 |
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Abstract 【Objective】To investigate the effects of ticagrelor or clopidogrel on the levels of miR-150, miR-133a, and miR-192 in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).【Methods】A total of 84 AMI patients who underwent PCI in two hospitals from March 2022 to December 2023 were enrolled. They were divided into the ticagrelor group and clopidogrel group according to the drugs used, with 42 cases in each group. The ticagrelor group received aspirin combined with ticagrelor after surgery, and the clopidogrel group received aspirin combined with clopidogrel, both for 3 months. Inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP)], cardiac function indices [left ventricular end-diastolic diameter (LVDD), left ventricular ejection fraction (LVEF)], incidence of adverse reactions, major adverse cardiovascular events (MACEs), and serum levels of miR-150, miR-133a, and miR-192 were compared between the two groups.【Results】 After treatment, serum levels of hs-CRP, IL-6, and TNF-α decreased in both groups, with the ticagrelor group significantly lower than the clopidogrel group (P<0.05). LVEF increased and LVDD decreased in both groups, with the ticagrelor group showing higher LVEF and lower LVDD than the clopidogrel group (P<0.05). The incidence of MACEs was significantly lower in the ticagrelor group (P<0.05), while there was no significant difference in adverse reaction rates between the two groups (P>0.05). After treatment, miR-133a and miR-192 were lower in both groups (with the ticagrelor group lower than the clopidogrel group), and miR-150 was higher (with the ticagrelor group higher than the clopidogrel group) (P<0.05).【Conclusion】Ticagrelor improves cardiac function and miRNA expression levels in AMI patients after PCI, with a lower incidence of MACEs.
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Received: 13 February 2025
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2025, Vol. 42 
