血清hs-CRP、SAA及D-D水平与老年尿毒症感染风险的相关性分析

doi:10.3969/j.issn.1671-7171.2025.07.010

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Abstract 【Objective】To explore the relationship of serum levels of high-sensitivity C-reactive protein (hs-CRP), serum amyloid A (SAA), and D-dimer (D-D) with the risk of infection in elderly patients with uremia.【Methods】A total of 92 elderly uremic patients were enrolled and divided into a non-infection group (n=70) and an infection group (n=22) based on bacterial culture results. General clinical data and serum levels of hs-CRP, SAA and D-D were compared between the two groups. Multivariate logistic regression was used to analyze the risk factors for infection in elderly uremic patients. The predictive value of these serum markers for infection was assessed using receiver operating characteristic (ROC) curve analysis.【Results】 There were no statistically significant differences between the two groups in terms of gender, age, duration of hemodialysis, or underlying kidney disease (P>0.05). Serum levels of hs-CRP, SAA and D-D were significantly lower in the non-infection group compared to the infection group (P<0.05). Multivariate logistic regression analysis showed that hs-CRP ≥ 31.780 mg/L, SAA ≥ 105.285 mg/L, and D-D ≥ 301.025 ng/mL were independent risk factors for infection in elderly patients with uremia (all P<0.05). ROC curve analysis demonstrated that serum hs-CRP, SAA, and D-D levels could predict the occurrence of infection in these patients (all P<0.05).【Conclusion】 Infection in elderly uremic patients is influenced by multiple factors. Elevated levels of serum hs-CRP, SAA, and D-D may indicate the presence of infection.

Key words： Uremia C-Reactive Protein Serum Amyloid A Protein Fibrin Fibrinogen Degradation Products Infections

Received: 18 October 2023

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R692.5

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	TAO Shoujian
	JIA Bei

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TAO Shoujian,JIA Bei. Correlation Analysis of Serum hs-CRP, SAA, and D-D Levels with the Risk of Infection in Elderly Patients with Uremia[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1138-1140.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.07.010 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I7/1138

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