心外膜脂肪厚度与炎症因子对房颤患者射频消融术后复发的预测价值<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2025.05.011

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Abstract 【Objective】 To investigate the value of epicardial adipose tissue thickness (EATT) and inflammatory factors in predicting recurrence after radiofrequency catheter ablation (RFCA) in patients with atrial fibrillation (AF).【Methods】 A total of 180 AF patients who underwent RFCA in our hospital were included in the study. According to follow-up results, they were divided into the recurrence group (61 cases) and the non-recurrence group (119 cases). The levels of EATT and inflammatory factors [high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8)] were compared between the two groups. Their relationship with AF recurrence and their predictive value were analyzed.【Results】 The recurrence group had significantly higher levels of EATT, hs-CRP, TNF-α, IL-6, and IL-8 than the non-recurrence group (P<0.05). Multivariate logistic regression analysis showed that EATT, hs-CRP, TNF-α, IL-6, and IL-8 were independent risk factors for AF recurrence after ablation (all OR>1, P<0.05). Receiver operating characteristic (ROC) curve analysis indicated that the combination of EATT and inflammatory factors had the highest predictive value for postoperative AF recurrence, with an area under the curve (AUC) of 0.974, sensitivity of 93.4%, and specificity of 96.6%.【Conclusion】 EATT and inflammatory factors are closely associated with AF recurrence after RFCA. Combined detection of EATT and inflammatory factors offers high sensitivity and specificity in predicting recurrence, which has important clinical value.

Key words： Atrial Fibrillation Radiofrequency Ablation Adipose Tissue Chemokines

Received: 03 December 2024

PACS:

R541.75

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.05.011 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I5/773

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